Nucleus Basalis Magnocellularis and Substantia Innominata Corticopetal Cholinergic Lesions Attenuate Freezing Induced by Predator Odor.
Previous studies have demonstrated that corticopetal cholinergic lesions applied to the nucleus basalis magnocellularis and substantia innominata (NBM/SI) attenuate operant suppression induced by aversive events. However, these lesions have no effect on open-arm behavior in the elevated plus-maze or...
| Publicado en: | Behavioral Neuroscience Vol. 122; no. 3; pp. 601 - 611 |
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| Autores principales: | , , , |
| Formato: | Artículo |
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American Psychological Association
June 2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=506800819&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 506800819 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: June 2008 vid: 122 iid: 3 pid: 34 pub: American Psychological Association artinfo: ui: 506800819 10.1037/0735-7044.122.3.601 ppf: 601 ppct: 10 formats: tig: atl: Nucleus Basalis Magnocellularis and Substantia Innominata Corticopetal Cholinergic Lesions Attenuate Freezing Induced by Predator Odor. aug: au: Knox, Dayan Brothers, Holly Norman, Greg J. Berntson, Gary G. su: Laboratory rats Fear Brain function localization Prefrontal cortex sug: subj: Laboratory rats Fear Brain function localization Prefrontal cortex ab: Previous studies have demonstrated that corticopetal cholinergic lesions applied to the nucleus basalis magnocellularis and substantia innominata (NBM/SI) attenuate operant suppression induced by aversive events. However, these lesions have no effect on open-arm behavior in the elevated plus-maze or changes in startle reactivity induced by bright light. This raises the possibility that NBM/SI corticopetal cholinergic lesions alter operant behavior and/or appetitive state, as opposed to the aversive state operant suppression is supposed to index. To address this concern, the authors documented the effect of NBM/SI corticopetal cholinergic lesions on freezing induced by a component of fox feces (2,4,5-trimethylthiazoline [TMT]), a paradigm that does not involve food deprivation or operant performance. TMT presentation induced freezing behavior, and this effect was attenuated by NBM/SI corticopetal cholinergic lesions. Because predator odor presentation, but not presentation of a predator, induces defense behaviors that are sensitive to anxiolytic drugs, the results of the study suggest that NBM/SI corticopetal cholinergic lesions attenuate anxiety-like states. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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