Prefrontal Control of Trace Eyeblink Conditioning in Rabbits: Role in Retrieval of the CR?
Rabbits (Oryctolagus cuniculus) were trained on a trace eyeblink (EB) conditioning task to a criterion of 10 consecutive EB conditioned responses (CRs). One week later, ibotenic acid or sham lesions were made in the mPFC centered on the prelimbic region (Brodmann's area 32) or the cingulate cortex (...
| Published in: | Behavioral Neuroscience Vol. 122; no. 4; pp. 841 - 849 |
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| Main Authors: | , , |
| Format: | Article |
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American Psychological Association
August 2008
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| Subjects: | |
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=506824399&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 506824399 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: August 2008 vid: 122 iid: 4 pid: 34 pub: American Psychological Association artinfo: ui: 506824399 10.1037/0735-7044.122.4.841 ppf: 841 ppct: 8 formats: tig: atl: Prefrontal Control of Trace Eyeblink Conditioning in Rabbits: Role in Retrieval of the CR? aug: au: Oswald, B. B. Maddox, S. A. Powell, D. A. su: Eyelids Reflexes Laboratory rabbits Brain function localization Prefrontal cortex sug: subj: Eyelids Reflexes Laboratory rabbits Brain function localization Prefrontal cortex ab: Rabbits (Oryctolagus cuniculus) were trained on a trace eyeblink (EB) conditioning task to a criterion of 10 consecutive EB conditioned responses (CRs). One week later, ibotenic acid or sham lesions were made in the mPFC centered on the prelimbic region (Brodmann's area 32) or the cingulate cortex (Brodmann's area 24). Following a 1-week postoperative recovery period, all animals were retrained for 4 consecutive days using the same parameters as during acquisition, given 1 week off, and retrained for another 4 days. Mean EB conditioning deficits in the group with area 32 lesions occurred on the first and second days of each retraining period. However, by the third and fourth days of retraining, these lesioned animals were performing at a level comparable to that of the sham group. Lesions of area 24 did not produce deficits at either retesting period. These findings were interpreted to indicate that area 32, but not area 24, is involved in retrieval processes, rather than consolidation or storage, in that the animals were impaired at both retesting times, but were able to relearn the task. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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