Neurotoxic Lesions of Retrosplenial Cortex Disrupt Signaled and Unsignaled Contextual Fear Conditioning.
The majority of research regarding contextual learning and memory has focused on the contributions of the hippocampus and related medial temporal lobe structures. However, little is known about other possible cortical contributions to these processes. Our laboratory recently demonstrated that electr...
| Publicado en: | Behavioral Neuroscience Vol. 122; no. 5; pp. 1070 - 1078 |
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| Autores principales: | , |
| Formato: | Artículo |
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American Psychological Association
October 2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=506848158&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 506848158 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: October 2008 vid: 122 iid: 5 pid: 34 pub: American Psychological Association artinfo: ui: 506848158 10.1037/a0012895 ppf: 1070 ppct: 8 formats: tig: atl: Neurotoxic Lesions of Retrosplenial Cortex Disrupt Signaled and Unsignaled Contextual Fear Conditioning. aug: au: Keene, Christopher S. Bucci, David J. su: Context effects (Psychology) Emotional conditioning Brain function localization Laboratory rats sug: subj: Context effects (Psychology) Emotional conditioning Brain function localization Laboratory rats ab: The majority of research regarding contextual learning and memory has focused on the contributions of the hippocampus and related medial temporal lobe structures. However, little is known about other possible cortical contributions to these processes. Our laboratory recently demonstrated that electrolytic lesions of the retrosplenial cortex (RSP), a posterior region of cingulate cortex, impaired contextual but not cue-specific fear conditioning. The present experiments further examined the role of RSP in contextual fear memory using fiber-sparing neurotoxic lesions and both signaled and unsignaled fear conditioning paradigms. Despite comparable acquisition of the conditioned fear response, rats with neurotoxic lesions of RSP exhibited impaired contextual memory relative to control animals in both the signaled and unsignaled paradigms. These results further suggest an important role for RSP in contextual learning and memory. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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