Impact of Continuous Versus Intermittent CS-UCS Pairing on Human Brain Activation During Pavlovian Fear Conditioning.
During Pavlovian fear conditioning a conditioned stimulus (CS) is repeatedly paired with an aversive unconditioned stimulus (UCS). In many studies the CS and UCS are paired on every trial, whereas in others the CS and UCS are paired intermittently. To better understand the influence of the CS-UCS pa...
| Published in: | Behavioral Neuroscience Vol. 121; no. 4; pp. 635 - 643 |
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| Main Authors: | , , |
| Format: | Article |
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American Psychological Association
August 2007
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| Subjects: | |
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=506866275&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 506866275 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: August 2007 vid: 121 iid: 4 pid: 34 pub: American Psychological Association artinfo: ui: 506866275 10.1037/0735-7044.121.4.635 ppf: 635 ppct: 8 formats: tig: atl: Impact of Continuous Versus Intermittent CS-UCS Pairing on Human Brain Activation During Pavlovian Fear Conditioning. aug: au: Dunsmoor, Joseph E. Bandettini, Peter A. Knight, David C. su: Brain -- Imaging Fear Emotional conditioning Brain function localization sug: subj: Brain -- Imaging Fear Emotional conditioning Brain function localization ab: During Pavlovian fear conditioning a conditioned stimulus (CS) is repeatedly paired with an aversive unconditioned stimulus (UCS). In many studies the CS and UCS are paired on every trial, whereas in others the CS and UCS are paired intermittently. To better understand the influence of the CS-UCS pairing rate on brain activity, the experimenters presented continuously, intermittently, and non-pa. ed CSs during fear conditioning. Amygdala, anterior cingulate, and fusiform gyrus activity increased linearly with the CS-UCS pairing rate. In contrast, insula and left dorsolateral prefrontal cortex responses were larger during intermittently paired CS presentations relative to continuously and non-paired CSs. These results demonstrate two distinct patterns of activity in disparate brain regions. Amygdala. anterior cingulate, and fusiform gyrus activity paralleled the CS-UCS pairing rate, whereas the insula and dorsolateral prefrontal cortex appeared to respond to the uncertainty inherent in intermittent CS-UCS pairing procedures. These findings may further clarify the role of these brain regions in Pavlovian fear conditioning. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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