Dopamine D1 Receptor Stimulation of the Nucleus Accumbens or the Medial Preoptic Area Promotes the Onset of Maternal Behavior in Pregnancy-Terminated Rats.
There is good evidence that interference with the mesolimbic dopamine (DA) system results in impaired maternal responding in postpartum female rats. However, whether activation of the mesolimbic DA system is capable of promoting maternal behavior has not been investigated. This study examined whethe...
| Publicado en: | Behavioral Neuroscience Vol. 121; no. 5; pp. 907 - 920 |
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| Autores principales: | , , , , , |
| Formato: | Artículo |
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American Psychological Association
October 2007
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=506889551&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 506889551 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: October 2007 vid: 121 iid: 5 pid: 34 pub: American Psychological Association artinfo: ui: 506889551 10.1037/0735-7044.121.5.907 ppf: 907 ppct: 13 formats: tig: atl: Dopamine D1 Receptor Stimulation of the Nucleus Accumbens or the Medial Preoptic Area Promotes the Onset of Maternal Behavior in Pregnancy-Terminated Rats. aug: au: Stolzenberg, Danielle S. McKenna, Jonathan B. Keough, Samantha Hancock, Rebecca Numan, Marilyn J. Numan, Michael su: Brain function localization Dopamine -- Receptors Parental behavior in animals Laboratory rats sug: subj: Brain function localization Dopamine -- Receptors Parental behavior in animals Laboratory rats ab: There is good evidence that interference with the mesolimbic dopamine (DA) system results in impaired maternal responding in postpartum female rats. However, whether activation of the mesolimbic DA system is capable of promoting maternal behavior has not been investigated. This study examined whether increasing DA activity in various brain regions of pregnancy-terminated, naive female rats would stimulate the onset of maternal behavior. Experiments 1 and 2 examined the effects of microinjection of various doses (0, 0.2, or 0.5 μg/0.5 (μ/side) of a D1 DA receptor agonist, SKF 38393, or a D2 DA receptor agonist, quinpirole, into the nucleus accumbens (NA) on latency to show full maternal behavior, and Experiment 3 determined the effects of SKF 38393 injection into a control site. Finally, because the medial preoptic area (MPOA) is also important for maternal behavior, receives DA input, and expresses DA receptors, the authors examined whether microinjection of SKF 38393 into MPOA was capable of stimulating the onset of maternal behavior. Results indicated that microinjection of SKF 38393 into either the NA or the MPOA facilitates maternal responding in pregnancy-terminated rats. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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