Lesions of the Fornix and Anterior Thalamic Nuclei Dissociate Different Aspects of Hippocampal-Dependent Spatial Learning: Implications for the Neural Basis of Scene Learning.
The present study used 2 different discrimination tasks designed to isolate distinct components of visuospatial learning: structural learning and geometric learning. Structural learning refers to the ability to learn the precise combination of stimulus identity with stimulus location. Rats with ante...
| Publicado en: | Behavioral Neuroscience Vol. 123; no. 3; pp. 504 - 520 |
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| Autores principales: | , , |
| Formato: | Artículo |
| Publicado: |
American Psychological Association
June 2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=506892388&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 506892388 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: June 2009 vid: 123 iid: 3 pid: 34 pub: American Psychological Association artinfo: ui: 506892388 10.1037/a0015404 ppf: 504 ppct: 16 formats: tig: atl: Lesions of the Fornix and Anterior Thalamic Nuclei Dissociate Different Aspects of Hippocampal-Dependent Spatial Learning: Implications for the Neural Basis of Scene Learning. aug: au: Aggleton, John P. Poirier, Guillaume L. Aggleton, Hugh S. su: Psychology of learning Spatial ability Hippocampus (Brain) Brain function localization Laboratory rats sug: subj: Psychology of learning Spatial ability Hippocampus (Brain) Brain function localization Laboratory rats ab: The present study used 2 different discrimination tasks designed to isolate distinct components of visuospatial learning: structural learning and geometric learning. Structural learning refers to the ability to learn the precise combination of stimulus identity with stimulus location. Rats with anterior thalamic lesions and fornix lesions were unimpaired on a configural learning task in which the rats learned 3 concurrent mirror-image discriminations (structural learning). Indeed, both lesions led to facilitated learning. In contrast, anterior thalamic lesions impaired the geometric discrimination (e.g., swim to the comer with the short wall to the right of the long wall). Finally, both the fornix and anterior thalamic lesions severely impaired T-maze alternation, a task that taxes an array of spatial strategies including allocentric learning. This pattern of dissociations and double dissociations highlights how distinct classes of spatial learning rely on different systems, even though they may converge on the hippocampus. Consequently, the findings suggest that structural learning is heavily dependent on cortico-hippocampal interactions. In contrast, subcortical inputs (such as those from the anterior thalamus) contribute to geometric learning. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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