A Behavioral Analysis of the Role of CA3 and CA1 Subcortical Efferents During Classical Fear Conditioning.
It has been proposed that the hippocampus and subcortical structures interact during the processing of fear and anxiety-related information. It has been demonstrated that the subcortical efferents from CA3 and CAl can be selectively disrupted without concomitant disruption to the afferents. The pres...
| Publicado en: | Behavioral Neuroscience Vol. 123; no. 3; pp. 624 - 631 |
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| Autores principales: | , , |
| Formato: | Artículo |
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American Psychological Association
June 2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=506892437&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 506892437 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: June 2009 vid: 123 iid: 3 pid: 34 pub: American Psychological Association artinfo: ui: 506892437 10.1037/a0015455 ppf: 624 ppct: 7 formats: tig: atl: A Behavioral Analysis of the Role of CA3 and CA1 Subcortical Efferents During Classical Fear Conditioning. aug: au: Hunsaker, Michael R. Tran, Giang T. Kesner, Raymond P. su: Laboratory rats Brain function localization Hippocampus (Brain) Emotional conditioning sug: subj: Laboratory rats Brain function localization Hippocampus (Brain) Emotional conditioning ab: It has been proposed that the hippocampus and subcortical structures interact during the processing of fear and anxiety-related information. It has been demonstrated that the subcortical efferents from CA3 and CAl can be selectively disrupted without concomitant disruption to the afferents. The present experiment was designed to evaluate the role of CA3 efferents via the fimbria and the CAI efferents via the dorsal fornix for encoding and consolidation/retrieval of classical fear conditioning. The present data suggest that the subcortical projections from CA3 and CAl are differentially involved in the processing of classical fear conditioning, with CA3 subcortical efferents supporting acquisition of both cued and contextual fear but only supporting retention of contextual fear and CA I subcortical efferents supporting the encoding and retrieval of both cued and contextual fear. These data further suggest that all hippocampal efferents are not homogeneous, and that the hippocampus and subcortex interact to process conditioned fear. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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