The Role of the Cerebellar Interpositus Nucleus in Short and Long Term Memory for Trace Eyeblink Conditioning.
In previous studies the cerebellar interpositus (IP) nucleus, but not the hippocampus, was shown to be necessary both for initial learning and retention and for long-term retention of the standard delay eyeblink conditioned response (CR). However, in the trace eyeblink CR procedure, the hippocampus...
| Published in: | Behavioral Neuroscience Vol. 123; no. 1; pp. 54 - 62 |
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| Main Authors: | , , |
| Format: | Article |
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American Psychological Association
February 2009
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| Subjects: | |
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=506897246&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 506897246 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: February 2009 vid: 123 iid: 1 pid: 34 pub: American Psychological Association artinfo: ui: 506897246 10.1037/a0014263 ppf: 54 ppct: 8 formats: tig: atl: The Role of the Cerebellar Interpositus Nucleus in Short and Long Term Memory for Trace Eyeblink Conditioning. aug: au: Pakaprot, Narawut Kim, Soyun Thompson, Richard F. su: Eyelids Reflexes Cerebellum Brain function localization Animal memory sug: subj: Eyelids Reflexes Cerebellum Brain function localization Animal memory ab: In previous studies the cerebellar interpositus (IP) nucleus, but not the hippocampus, was shown to be necessary both for initial learning and retention and for long-term retention of the standard delay eyeblink conditioned response (CR). However, in the trace eyeblink CR procedure, the hippocampus is also necessary for initial learning arid retention, but not for long-term retention. Here the authors evaluate the role of the IP nucleus in both initial learning and retention, and in long-term retention of the trace eyeblink CR, using muscimol infusion to reversibly inactivate the IP nucleus. For the short-term study, there were two subgroups, the first sequentially passed through acquisition, inactivation, and reacquisition phases, whereas the second subgroup went through inactivation, acquisition, and inactivation phases. For the long-term study, the rabbits acquired the CR and then rested for a month. Next, they were distributed into two subgroups: with or without retention training, and finally went through inactivation and reacquisition phases. The results showed that the prelearning IP nucleus inactivation prevented the acquisition of the trace CR, whereas the postlearning inactivation reversibly abolished the expression of both the short- and long-term CR. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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