Tegmental Pedunculopontine Glutamate and GABA-B Synapses Mediate Morphine Reward.
The tegmental pedunculopontine nucleus (TPP) of the midbrain is critical in mediating the acute rewarding effects of opiates. However, the circuitry and neurochemistry underlying this effect has not been determined. Here we identify TPP receptors and cell types involved in systemic morphine reward a...
| Publicado en: | Behavioral Neuroscience Vol. 123; no. 1; pp. 145 - 156 |
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| Autores principales: | , , |
| Formato: | Artículo |
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American Psychological Association
February 2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=506897308&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 506897308 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: February 2009 vid: 123 iid: 1 pid: 34 pub: American Psychological Association artinfo: ui: 506897308 10.1037/a0014015 ppf: 145 ppct: 11 formats: tig: atl: Tegmental Pedunculopontine Glutamate and GABA-B Synapses Mediate Morphine Reward. aug: au: Heinmiller, Andrew Ting-A-Kee, Ryan Vargas-Perez, Hector su: Laboratory rats Reward (Psychology) Brain function localization Brain stem sug: subj: Laboratory rats Reward (Psychology) Brain function localization Brain stem ab: The tegmental pedunculopontine nucleus (TPP) of the midbrain is critical in mediating the acute rewarding effects of opiates. However, the circuitry and neurochemistry underlying this effect has not been determined. Here we identify TPP receptors and cell types involved in systemic morphine reward and suggest an anatomical and neurochemical model for reward in the TPP. Simple hypothetical anatomical models for serial cell arrangements and receptors in the TPP were proposed and predictions of behavioral outcome (reward or no reward) then were made, based on the administration of agonists and antagonists directly into the TPP of rats. We report that TPP-administered NMDA produced rewarding effects, although GABA agonists and antagonists had no motivational effects on their own. However, the NMDA receptor antagonist AP-7 and the GABA-B receptor antagonist saclofen, while having no motivational effects on their own, blocked systemic morphine reward as measured by conditioned place preference. These results provide positive evidence for GABA-B and glutamate synapses in the TPP, which mediates systemic morphine reward and suggest that a serial pathway for morphine reward in the TPP is unlikely. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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