Temporary Inactivation of Ventral Tegmental Area Neurons With Either Muscimol or Baclofen Reversibly Disrupts Maternal Behavior in Rats Through Different Underlying Mechanisms.
The purpose of this study was to examine the effects of inactivation of ventral tegmental area (VTA) projection neurons, while sparing fibers of passage, on maternal behavior in rats. Because VTA neurons contain GABA-A and GABA-B receptors, the effects of muscimol or baclofen were studied. Although...
| Published in: | Behavioral Neuroscience Vol. 123; no. 4; pp. 740 - 752 |
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| Main Authors: | , , |
| Format: | Article |
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American Psychological Association
August 2009
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| Subjects: | |
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=506914131&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 506914131 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: August 2009 vid: 123 iid: 4 pid: 34 pub: American Psychological Association artinfo: ui: 506914131 10.1037/a0016204 ppf: 740 ppct: 12 formats: tig: atl: Temporary Inactivation of Ventral Tegmental Area Neurons With Either Muscimol or Baclofen Reversibly Disrupts Maternal Behavior in Rats Through Different Underlying Mechanisms. aug: au: Numan, Michael Stolzenberg, Danielle S. Dellevigne, Amanda A. su: Laboratory rats Parental behavior in animals Brain function localization sug: subj: Laboratory rats Parental behavior in animals Brain function localization ab: The purpose of this study was to examine the effects of inactivation of ventral tegmental area (VTA) projection neurons, while sparing fibers of passage, on maternal behavior in rats. Because VTA neurons contain GABA-A and GABA-B receptors, the effects of muscimol or baclofen were studied. Although bilateral injections of either drug into the VTA disrupted maternal behavior, it is likely that they did so through different underlying mechanisms. Muscimol disrupted both retrieval of pups and nursing behavior, while causing stereotyped motor activity. Baclofen disrupted retrieval behavior without affecting nursing behavior, and control injections of baclofen into the region dorsal to VTA were ineffective. The effects of VTA baclofen on maternal behavior are similar to the effects of interference with mesolimbic dopamine (DA) function. The case is made that muscimol probably caused a hyper-excitation of VTA DA neurons through a process of disinhibition. In contrast, baclofen may have depressed the activity of all VTA projection neurons, including VTA DA neurons. Baclofen is a promising tool to explore whether medial preoptic area neurons interact with VTA neurons to control active maternal responses. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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