Factors Governing Single-Trial Contextual Fear Conditioning in the Weanling Rat.
Although contextual fear conditioning emerges later in development than explicit-cue fear conditioning, little is known about the stimulus parameters and biological substrates required at early ages. The authors adapted methods for investigating hippocampus function in adult rodents to identify dete...
| Publicado en: | Behavioral Neuroscience Vol. 123; no. 5; pp. 1148 - 1153 |
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| Autores principales: | , , |
| Formato: | Artículo |
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American Psychological Association
October 2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=506936167&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 506936167 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: October 2009 vid: 123 iid: 5 pid: 34 pub: American Psychological Association artinfo: ui: 506936167 10.1037/a0016733 ppf: 1148 ppct: 5 formats: tig: atl: Factors Governing Single-Trial Contextual Fear Conditioning in the Weanling Rat. aug: au: Burman, M. A. Murawski, N. J. Schiffino, F. L. su: Fear Conditioned response Brain function localization Hippocampus (Brain) sug: subj: Fear Conditioned response Brain function localization Hippocampus (Brain) ab: Although contextual fear conditioning emerges later in development than explicit-cue fear conditioning, little is known about the stimulus parameters and biological substrates required at early ages. The authors adapted methods for investigating hippocampus function in adult rodents to identify determinants of contextual fear conditioning in developing rats. Experiment 1 examined the duration of exposure required by weanling rats at postnatal day (PND) 23 to demonstrate contextual fear conditioning. This experiment demonstrated that 30 s of context exposure is sufficient to support conditioning. Furthermore, preexposure enhanced conditioning to an immediate footshock, the context preexposure facilitation effect (CPFE), but had no effect on contextual conditioning to a delayed shock. Experiment 2 demonstrated that N-methyl-D-aspartate (NMDA) receptor inactivation during preexposure impairs contextual learning at PND 23. Thus, the conjuctive representations underlying the CPFE are NMDA-dependent as early as PND23 in the rat. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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