Double Dissociation and Hierarchical Organization of Strategy Switches and Reversals in the Rat PFC.
Prelimbic-infralimbic cortex (PL-IL) and orbitofrontal cortex (OFC) influence behavioral flexibility in the rat. The authors tested the effects of PL-IL or OFC infusion with the GABA agonist muscimol in the context of 2 flexible responding tasks: strategy switching and reversal. Muscimol infusion in...
| Published in: | Behavioral Neuroscience Vol. 123; no. 5; pp. 1028 - 1036 |
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| Main Authors: | , |
| Format: | Article |
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American Psychological Association
October 2009
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| Subjects: | |
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=506936215&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 506936215 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: October 2009 vid: 123 iid: 5 pid: 34 pub: American Psychological Association artinfo: ui: 506936215 10.1037/a0016822 ppf: 1028 ppct: 8 formats: tig: atl: Double Dissociation and Hierarchical Organization of Strategy Switches and Reversals in the Rat PFC. aug: au: Young, James J. Shapiro, Matthew L. su: Psychology of learning Neurophysiology Brain function localization Cerebral cortex sug: subj: Psychology of learning Neurophysiology Brain function localization Cerebral cortex ab: Prelimbic-infralimbic cortex (PL-IL) and orbitofrontal cortex (OFC) influence behavioral flexibility in the rat. The authors tested the effects of PL-IL or OFC infusion with the GABA agonist muscimol in the context of 2 flexible responding tasks: strategy switching and reversal. Muscimol infusion into PL-IL impaired retention of strategy switches but not reversals, whereas muscimol infusion into OFC impaired retention of reversals but not switches. However, whereas training in repeated reversals did not remove the requirement of PL-IL for switch retention (E. L. Rich & M. L. Shapiro, 2007), training in repeated switches did remove the requirement of OFC for reversal retention. Thus, activity during strategy switches was sufficient to initiate learning and remove the requirement of OFC in later reversals. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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