Amygdala-Dependent Fear Conditioning in Humans is Modulated by the BDNFval66met Polymorphism.
The brain-derived neurotrophic factor (BDNF) is critically involved in neuroplasticity, as well as the acquisition, consolidation, and retention of hippocampal- and amygdala-dependent learning. A common functional A --> G single nucleotide polymorphism (BDNFval66met) in the prodomain of the human BD...
| Publicado en: | Behavioral Neuroscience Vol. 124; no. 1; pp. 9 - 16 |
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| Autores principales: | , , |
| Formato: | Artículo |
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American Psychological Association
February 2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=506986789&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 506986789 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: February 2010 vid: 124 iid: 1 pid: 34 pub: American Psychological Association artinfo: ui: 506986789 10.1037/a0018261 ppf: 9 ppct: 7 formats: tig: atl: Amygdala-Dependent Fear Conditioning in Humans is Modulated by the BDNFval66met Polymorphism. aug: au: Lonsdorf, Tina B. Weike, Almut I. Golkar, Armita su: Genetic polymorphisms Brain-derived neurotrophic factor Brain function localization Amygdaloid body Conditioned response Fear sug: subj: Genetic polymorphisms Brain-derived neurotrophic factor Brain function localization Amygdaloid body Conditioned response Fear ab: The brain-derived neurotrophic factor (BDNF) is critically involved in neuroplasticity, as well as the acquisition, consolidation, and retention of hippocampal- and amygdala-dependent learning. A common functional A --> G single nucleotide polymorphism (BDNFval66met) in the prodomain of the human BDNF gene is associated with abnormal intracellular trafficking and reduced activity-dependent BDNF release. We studied the effect of BDNFval66met in an aversive differential fear conditioning, and a delayed extinction paradigm in 57 healthy participants. Pictures of male faces were used as stimuli and fear learning was quantified by fear potentiated startle (FPS) and skin conductance responses (SCR). Aware BDNF met-carriers show a deficit in amygdala-dependent fear conditioning as indicated by an absence of FPS responses in the last acquisition block. This deficit was maintained in the first block of extinction. No genotype differences were found in conditioned SCR discrimination. These data provide evidence for the involvement of BDNF signaling in human amygdala-dependent learning. We suggest that the BDNF met-allele may have a protective effect for the development of affective pathologies that may be mediated via reduced synaptic plasticity induced by negative experience. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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