The “Good” Limb Makes the “Bad” Limb Worse: Experience-Dependent Interhemispheric Disruption of Functional Outcome After Cortical Infarcts in Rats.
Following stroke-like lesions to the sensorimotor cortex in rats, experience with the ipsi-to-lesion (ipsilesional), “nonparetic”, forelimb worsens deficits in the contralesional, “paretic”, forelimb. We tested whether the maladaptive effects of experience with the nonparetic limb are mediated throu...
| Publicado en: | Behavioral Neuroscience Vol. 124; no. 1; pp. 124 - 133 |
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| Autores principales: | , , |
| Formato: | Artículo |
| Publicado: |
American Psychological Association
February 2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=506986847&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 506986847 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: February 2010 vid: 124 iid: 1 pid: 34 pub: American Psychological Association artinfo: ui: 506986847 10.1037/a0018457 ppf: 124 ppct: 9 formats: tig: atl: The “Good” Limb Makes the “Bad” Limb Worse: Experience-Dependent Interhemispheric Disruption of Functional Outcome After Cortical Infarcts in Rats. aug: au: Allred, Rachel P. Cappellini, Colleen H. Jones, Theresa A. su: Cerebral cortex Cerebral infarction Brain -- Innervation Limbic system Brain function localization sug: subj: Cerebral cortex Cerebral infarction Brain -- Innervation Limbic system Brain function localization ab: Following stroke-like lesions to the sensorimotor cortex in rats, experience with the ipsi-to-lesion (ipsilesional), “nonparetic”, forelimb worsens deficits in the contralesional, “paretic”, forelimb. We tested whether the maladaptive effects of experience with the nonparetic limb are mediated through callosal connections and the contralesional sensorimotor cortex. Adult male rats with proficiency in skilled reaching with their dominant (for reaching) forelimb received ischemic bilateral sensorimotor cortex lesions, or unilateral lesions, with or without callosal transections. After assessing dominant forelimb function (the paretic forelimb in rats with unilateral lesions), animals were trained with their nonparetic/nondominant forelimb or underwent control procedures for 15 days. Animals were then tested with their paretic/dominant forelimb. In animals with unilateral lesions only, nonparetic forelimb training worsened subsequent performance with the paretic forelimb, as found previously. This effect was not found in animals with both callosal transections and unilateral lesions. After bilateral lesions, training the nondominant limb did not worsen function of the dominant limb compared with controls. Thus, the maladaptive effects of training the nonparetic limb on paretic forelimb function depend upon the contralesional cortex and transcallosal projections. This suggests that this experience-dependent disruption of functional recovery is mediated through interhemispheric connections of the sensorimotor cortex. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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