Dietary Cholesterol Impairs Memory and Memory Increases Brain Cholesterol and Sulfatide Levels.
Cholesterol and sulfatides play many important roles in learning and memory. To date, our observations about the effects of cholesterol on learning have been assessed during response acquisition: that is, the learning of a new memory. Here, we report for the first time to our knowledge, on the effec...
| Publicado en: | Behavioral Neuroscience Vol. 124; no. 1; pp. 115 - 124 |
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| Autores principales: | , , |
| Formato: | Artículo |
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American Psychological Association
February 2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=506986855&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 506986855 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: February 2010 vid: 124 iid: 1 pid: 34 pub: American Psychological Association artinfo: ui: 506986855 10.1037/a0018253 ppf: 115 ppct: 9 formats: tig: atl: Dietary Cholesterol Impairs Memory and Memory Increases Brain Cholesterol and Sulfatide Levels. aug: au: Darwish, Deya S. Wang, Desheng Konat, Gregory W. su: Memory Brain function localization Blood cholesterol sug: subj: Memory Brain function localization Blood cholesterol keyword: Sulfatides ab: Cholesterol and sulfatides play many important roles in learning and memory. To date, our observations about the effects of cholesterol on learning have been assessed during response acquisition: that is, the learning of a new memory. Here, we report for the first time to our knowledge, on the effect of a cholesterol diet on a previously formed memory. Rabbits were given trace conditioning of the nictitating membrane response for 10 days, then fed a 2% cholesterol diet for 8 weeks, and then assessed for memory recall of the initially learned task. We show that dietary cholesterol had an adverse effect on memory recall. Second, we investigated whether dietary cholesterol caused an increase in brain cholesterol and sulfatide levels in four major brain structures (hippocampus, frontal lobe, brainstem, and cerebellum) using a technique for analyzing myelin and myelin-free fractions separately. Although our data confirm previous findings that dietary cholesterol does not directly affect cholesterol and establish that it does not affect sulfatide levels in the brain, these levels did increase rather significantly in the hippocampus and frontal lobe as a function of learning and memory. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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