Molecular Modulation of Prefrontal Cortex: Rational Development of Treatments for Psychiatric Disorders.
Dysfunction of the prefrontal cortex (PFC) is a central feature of many psychiatric disorders, such as attention deficit hyperactivity disorder (ADHD), posttraumatic stress disorder (PTSD), schizophrenia, and bipolar disorder. Thus, understanding molecular influences on PFC function through basic re...
| Publicado en: | Behavioral Neuroscience Vol. 125; no. 3; pp. 282 - 297 |
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| Autores principales: | , |
| Formato: | Artículo |
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American Psychological Association
June 2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=507174160&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 507174160 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: June 2011 vid: 125 iid: 3 pid: 34 pub: American Psychological Association artinfo: ui: 507174160 10.1037/a0023165 ppf: 282 ppct: 15 formats: tig: atl: Molecular Modulation of Prefrontal Cortex: Rational Development of Treatments for Psychiatric Disorders. aug: au: Gamo, Nao J. Arnsten, Amy F. T. su: Brain function localization Prefrontal cortex Mental illness treatment Noradrenaline Dopamine Psychological stress sug: subj: Brain function localization Prefrontal cortex Mental illness treatment Noradrenaline Dopamine Psychological stress ab: Dysfunction of the prefrontal cortex (PFC) is a central feature of many psychiatric disorders, such as attention deficit hyperactivity disorder (ADHD), posttraumatic stress disorder (PTSD), schizophrenia, and bipolar disorder. Thus, understanding molecular influences on PFC function through basic research in animals is essential to rational drug development. In this review, we discuss the molecular signaling events initiated by norepinephrine and dopamine that strengthen working memory function mediated by the dorsolateral PFC under optimal conditions, and weaken working memory function during uncontrollable stress. We also discuss how these intracellular mechanisms can be compromised in psychiatric disorders, and how novel treatments based on these findings may restore a molecular environment conducive to PFC regulation of behavior, thought and emotion. Examples of successful translation from animals to humans include guanfacine for the treatment of ADHD and related PFC disorders, and prazosin for the treatment of PTSD. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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