Biomedical advances in developmental psychology: the case of fragile X syndrome.
Fragile X syndrome, the most common inherited cause of mental retardation, is caused by an abnormal gene on the bottom end of the X chromosome. Discovered and sequenced in 1991, it is called the Fragile X Mental Retardation-1 (FMR-1) gene. Mutations in the FMR-1 gene include small expansions with...
| Publicado en: | Developmental Psychology Vol. 32; pp. 416 - 425 |
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| Formato: | Artículo |
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American Psychological Association
May 1996
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=507492795&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 507492795 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00121649 DPS jtl: Developmental Psychology issn: 00121649 maglogo: N pubinfo: dt: May 1996 vid: 32 pid: 34 pub: American Psychological Association artinfo: ui: 507492795 10.1037/0012-1649.32.3.416 ppf: 416 ppct: 9 formats: tig: atl: Biomedical advances in developmental psychology: the case of fragile X syndrome. aug: au: Hagerman, Randi Jenssen su: Fragile X syndrome Behavior genetics Genetics sug: subj: Fragile X syndrome Behavior genetics Genetics ab: Fragile X syndrome, the most common inherited cause of mental retardation, is caused by an abnormal gene on the bottom end of the X chromosome. Discovered and sequenced in 1991, it is called the Fragile X Mental Retardation-1 (FMR-1) gene. Mutations in the FMR-1 gene include small expansions with a CGG (a specific sequence of the nucleotides) repetitive sequence that repeats from 50 to 200 times (the premutation) and the full mutation that involves a CGG repeat sequence that is greater than 200. In the full mutation, the FMR-1 gene is usually methylated, turning off the gene so that no protein is produced. Mutations within the FMR-1 gene can cause a spectrum of learning difficulties ranging from mild problems to severe mental retardation. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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