Reduced activation in right lateral prefrontal cortex and anterior cingulate gyrus in medication-naïve adolescents with attention deficit hyperactivity disorder during time discrimination.
Background: Patients with attention deficit hyperactivity disorder (ADHD) under-perform when discriminating between durations differing by several hundred milliseconds. This function involves right prefrontal and anterior cingulate (AC) brain regions, which are structurally and functionally compromi...
| Publicado en: | Journal of Child Psychology & Psychiatry & Allied Disciplines. Vol. 49; no. 9; pp. 977 - 986 |
|---|---|
| Autores principales: | , , , , |
| Formato: | Artículo |
| Publicado: |
HWW Temp
September 2008
|
| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=507996509&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 507996509 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00219630 D9TW jtl: Journal of Child Psychology & Psychiatry & Allied Disciplines. issn: 00219630 maglogo: N pubinfo: dt: September 2008 vid: 49 iid: 9 pid: 71778 pub: HWW Temp artinfo: ui: 507996509 10.1111/j.1469-7610.2008.01870.x ppf: 977 ppct: 9 formats: tig: atl: Reduced activation in right lateral prefrontal cortex and anterior cingulate gyrus in medication-naïve adolescents with attention deficit hyperactivity disorder during time discrimination. aug: au: Smith, Anna B. Taylor, Eric Brammer, Michael Halari, Rozmin Rubia, Katya su: Time perception Attention-deficit hyperactivity disorder Brain function localization Youth with mental illness sug: subj: Time perception Attention-deficit hyperactivity disorder Brain function localization Youth with mental illness ab: Background: Patients with attention deficit hyperactivity disorder (ADHD) under-perform when discriminating between durations differing by several hundred milliseconds. This function involves right prefrontal and anterior cingulate (AC) brain regions, which are structurally and functionally compromised in this patient group during executive tasks. We investigated the neuro-anatomical substrates mediating fine temporal discrimination in adolescents with ADHD compared with controls, using functional magnetic resonance imaging (fMRI). Methods: Twenty-one male medication-naïve adolescents aged 10-15 years with a DSM-IV diagnosis of ADHD (combined subtype) and without comorbid Axis I disorders (except conduct disorder) were compared to a group of 17 age- and IQ-matched healthy adolescents. Using fMRI on a 1.5T scanner, we compared brain activation and performance between adolescents with ADHD and controls during a time discrimination task contrasted with a temporal order task. Results: Despite comparable performance, patients with ADHD showed decreased activation in right dorsolateral and inferior prefrontal cortex and AC during time discrimination compared with controls. Conclusions: Right hemispheric fronto-cingulate abnormalities in ADHD, previously observed during inhibitory and executive functions, are also associated with temporal perception. Furthermore, recruitment of medication-naïve patients precludes the possibility that deficits are attributable to stimulant exposure. Reprinted by permission of the publisher. pubtype: Periodical doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
|---|