| Sumario: | The association between psychosocial stress and cocaine dependence was investigated. Stress in 36 non-treatment-seeking individuals enrolled in a brain imaging protocol was assessed using computerized multidimensional instruments, including the Speilberger State-Trait Anxiety Inventory (STAI). High stress levels were associated with a longer duration of cocaine use than were low stress levels, despite similarity in other characteristics of addiction severity. Statistically significant differences on both trait and state STAI scales indicated that this association is stable and not only evident in the context of recent cocaine use. The findings replicate those of prior reports implicating stress in the course of cocaine dependence and extend the associations between stress, negative affective states, and cocaine use to a non-treatment-seeking population.
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