Putamen Lesions and the Development of Attention-Deficit/Hyperactivity Symptomatology.
Objective: To investigate the association between focal stroke lesions of the putamen and either attention-deficit/hyperactivity disorder or traits of the disorder (ADHD/Traits). Method: Twenty-five children with focal stroke lesions were studied with standardized psychiatric assessments and anatomi...
| Publicado en: | Journal of the American Academy of Child & Adolescent Psychiatry Vol. 41; no. 5; pp. 563 - 572 |
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| Autores principales: | , , |
| Formato: | Artículo |
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Elsevier Science
May 2002
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=510218201&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 510218201 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 08908567 JAM jtl: Journal of the American Academy of Child & Adolescent Psychiatry issn: 08908567 maglogo: N pubinfo: dt: May 2002 vid: 41 iid: 5 pid: 467 pub: Elsevier Science artinfo: ui: 510218201 10.1097/00004583-200205000-00014 ppf: 563 ppct: 9 formats: tig: atl: Putamen Lesions and the Development of Attention-Deficit/Hyperactivity Symptomatology. aug: au: Max, Jeffrey E. Fox, Peter T. Lancaster, Jack L. su: Attention-deficit hyperactivity disorder Brain function localization Cerebrovascular disease patients Brain-damaged children Psychology sug: subj: Attention-deficit hyperactivity disorder Brain function localization Cerebrovascular disease patients Brain-damaged children Psychology ab: Objective: To investigate the association between focal stroke lesions of the putamen and either attention-deficit/hyperactivity disorder or traits of the disorder (ADHD/Traits). Method: Twenty-five children with focal stroke lesions were studied with standardized psychiatric assessments and anatomic brain magnetic resonance imaging. The pattern of lesion overlap in subjects with ADHD/Traits was determined. Results: Fifteen of 25 subjects had ADHD/Traits. The densest area of overlapping lesions (n = 7) in subjects with ADHD/Traits included the posterior ventral putamen. The median lesion volume was 9.7cm3, and the distribution was highly skewed. Lesion volume was not associated with ADHD/Traits. Therefore the following analyses focused on the 13 subjects with lesions < 10cm3: ADHD/Traits were exhibited in 6/7 subjects with putamen lesions versus 2/6 with no putamen lesions (Fisher exact test p = .1). Half (4/8) of the subjects with ADHD/Traits had overlapping lesions encompassing the posterior ventral putamen. None of the 5 subjects without ADHD/Traits had lesions in this empirically derived region of interest (Fisher exact test p = .1). Conclusions: Lesions within the dopamine-rich ventral putamen, which is part of the ventral or limbic striatum, tended to increase the risk of ADHD/Traits. ADHD/Traits may therefore be a disinhibition syndrome associated with dysfunction in this cortical-striato-thalamocortical loop. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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