Maturation of Brain Function Associated With Response Inhibition.
Objective: To investigate the developmental trajectory of response inhibition and, more specifically, whether there is a dissociation of function in the prefrontal cortex over the course of development of executive function and associated response inhibition abilities. Method: Nineteen typically dev...
| Publicado en: | Journal of the American Academy of Child & Adolescent Psychiatry Vol. 41; no. 10; pp. 1231 - 1239 |
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| Autores principales: | , , |
| Formato: | Artículo |
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Elsevier Science
October 2002
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=510259184&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 510259184 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 08908567 JAM jtl: Journal of the American Academy of Child & Adolescent Psychiatry issn: 08908567 maglogo: N pubinfo: dt: October 2002 vid: 41 iid: 10 pid: 467 pub: Elsevier Science artinfo: ui: 510259184 10.1097/00004583-200210000-00013 ppf: 1231 ppct: 8 formats: tig: atl: Maturation of Brain Function Associated With Response Inhibition. aug: au: Tamm, Leanne Menon, Vinod Reiss, Allan L. su: Response inhibition Cognitive development Prefrontal cortex Age (Psychology) sug: subj: Response inhibition Cognitive development Prefrontal cortex Age (Psychology) ab: Objective: To investigate the developmental trajectory of response inhibition and, more specifically, whether there is a dissociation of function in the prefrontal cortex over the course of development of executive function and associated response inhibition abilities. Method: Nineteen typically developing subjects, ranging in age from 8 to 20, performed a Go/NoGo task while behavioral and functional magnetic resonance imaging (fMRI) data were collected. Results: All subjects performed the task with few errors of omission and commission. No relationship between accuracy and age emerged, but the ability to inhibit responses more quickly significantly improved with age. Analyses of fMRI data revealed a positive correlation between activation and age in the left inferior frontal gyrus/insula/orbitofrontal gyrus, and a negative correlation between activation and age in the left middle/superior frontal gyri. Conclusion: These data provide the first evidence of dissociable processes occurring in the prefrontal cortex during development of executive functions associated with response inhibition: (1) Younger subjects activate more extensively than older subjects in discrete regions of the prefrontal cortex, presumably due to increased demands and inefficient recruitment of brain regions subserving executive functions including working memory. (2) Older subjects show increasingly focal activation in specific regions thought to play a more critical role in response inhibition. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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