Overseas processing of dried blood spots for timely diagnosis of HIV in Haitian infants.
Objective. To determine the feasibility of sending dried blood spots (DBS) to cm overseas processing center for the diagnosis of HIV infection in infants in rural Haiti. Methods. The program took place in the Central Department of Haiti. Children under 18 months of age who were born to an HIV-infect...
| Published in: | Pan American Journal of Public Health Vol. 24; no. 5; pp. 331 - 336 |
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| Main Authors: | , , , , , |
| Format: | Article |
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Pan American Health Organization
Nov2008
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=510722719&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 510722719 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 10204989 I3S jtl: Pan American Journal of Public Health issn: 10204989 maglogo: N pubinfo: dt: Nov2008 vid: 24 iid: 5 pid: 13497 pub: Pan American Health Organization artinfo: ui: 510722719 10.1590/S1020-49892008001100005 ppf: 331 ppct: 5 formats: fmt: – @attributes: type: T – @attributes: type: P size: 1.8MB tig: atl: Overseas processing of dried blood spots for timely diagnosis of HIV in Haitian infants. aug: au: Ivers, Louise C. Smith Fawzi, Mary Catherine Mann, Julie Jerome, Jean-Gregory Raymonville, Maxi Mukherjee, Joia S. su: AIDS diagnosis AIDS in children AIDS Rural children Haiti sug: subj: Haiti AIDS diagnosis AIDS in children AIDS Rural children ab: Objective. To determine the feasibility of sending dried blood spots (DBS) to cm overseas processing center for the diagnosis of HIV infection in infants in rural Haiti. Methods. The program took place in the Central Department of Haiti. Children under 18 months of age who were born to an HIV-infected mother or who had a positive HIV antibody test had blood collected on filter paper. Once dry, specimens were labeled with a unique identifying number, placed in sealed gas-impermeable envelopes containing a desiccant, stored at room temperature, and mailed to a commercial laboratory in The Netherlands, where blood was eluted from the filter paper and analyzed by the RetinaTM rainbow HIV-1 RNA assay. Infants were tested at 1 month of age and again at 4 months of age. Results. The DBS protocol was easily scaled up. During the study period, 138 infants had HIV status confirmed; 15 of them were found to be HIV infected and were enrolled in appropriate HIV care, and 123 were confirmed to be HIV uninfected, avoiding unnecessary prophylactic antibiotics and providing reassurance to caregivers. Conclusion. Central, overseas processing of DBS is a feasible solution for the timely diagnosis of HIV infection in infants where local capacity is unavailable. Regional processing centers for DBS could improve the access of millions of children in Latin America and the Caribbean to timely diagnosis of HIV infection. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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