Lower Orbital Frontal White Matter Integrity in Adolescents With Bipolar I Disorder.
Objective: To examine white matter microstructure, as assessed via diffusion tensor imaging (DTI), in adolescents with bipolar I disorder compared with control volunteers. Method: Twenty-six (12 male and 14 female subjects) adolescents (mean age, 16.0 years) with bipolar I disorder and 26 (14 male a...
| Publicado en: | Journal of the American Academy of Child & Adolescent Psychiatry Vol. 48; no. 1; pp. 79 - 87 |
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| Autores principales: | , , , , , , |
| Formato: | Artículo |
| Publicado: |
Elsevier Science
January 2009
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=510743489&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 510743489 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 08908567 JAM jtl: Journal of the American Academy of Child & Adolescent Psychiatry issn: 08908567 maglogo: N pubinfo: dt: January 2009 vid: 48 iid: 1 pid: 467 pub: Elsevier Science artinfo: ui: 510743489 10.1097/CHI.0b013e3181900421 ppf: 79 ppct: 8 formats: tig: atl: Lower Orbital Frontal White Matter Integrity in Adolescents With Bipolar I Disorder. aug: au: Kafantaris, Vivian Kingsley, Peter Ardekani, Babak Saito, Ema Lencz, Todd Lim, Kelvin Szeszko, Philip su: Brain -- Abnormalities Youth with mental illness Bipolar disorder Brain function localization sug: subj: Brain -- Abnormalities Youth with mental illness Bipolar disorder Brain function localization ab: Objective: To examine white matter microstructure, as assessed via diffusion tensor imaging (DTI), in adolescents with bipolar I disorder compared with control volunteers. Method: Twenty-six (12 male and 14 female subjects) adolescents (mean age, 16.0 years) with bipolar I disorder and 26 (14 male and 12 female subjects) control volunteers (mean age, 15.3 years) completed structural and DTI examinations. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) maps were compared between groups in the brain white matter using a voxelwise analysis after intersubject registration to Talairach space. Exploratory analyses were performed to assess structure-function correlations in a subgroup of 11 patients with available neuropsychological measures. Results: Compared with the control volunteers, the patients demonstrated abnormalities in white matter regions predicted to differ a priori between groups, including lower FA in the right orbital frontal lobe and higher ADC in the right and left subgenual region (p < .005, uncorrected; cluster size ≥ 100). There were no areas of higher FA or lower ADC in patients compared with control volunteers. Lower FA across regions that differed significantly between groups correlated significantly with slower visuomotor speed among patients with bipolar disorder. Conclusions: Abnormalities involving the orbital frontal and subgenual white matter in adolescents with bipolar disorder are consistent with neurobiological models that implicate dysregulation of affective systems and impulsivity in the pathophysiology of the disorder. Preliminary findings suggest that white matter abnormalities in pediatric bipolar disorder have functional correlates and may be useful in constructing neurobiological models of the disorder. J. Am. Acad. Child Adolesc. Psychiatry; 2009;48(1):79-86. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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