Increased Intrasubject Variability in Response Time in Youths With Bipolar Disorder and At-Risk Family Members.
Objective: Deficits in sustained attention may represent an endophenotype for bipolar disorder (BD). One heritable measure of sustained attention is intrasubject variability in response time (ISV-RT). We tested the hypothesis that, compared with controls, both youths with BD and those at familial ri...
| Publicado en: | Journal of the American Academy of Child & Adolescent Psychiatry Vol. 48; no. 6; pp. 628 - 636 |
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| Autores principales: | , , , , |
| Formato: | Artículo |
| Publicado: |
Elsevier Science
June 2009
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=510810555&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 510810555 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 08908567 JAM jtl: Journal of the American Academy of Child & Adolescent Psychiatry issn: 08908567 maglogo: N pubinfo: dt: June 2009 vid: 48 iid: 6 pid: 467 pub: Elsevier Science artinfo: ui: 510810555 10.1097/CHI.0b013e3181a27527 ppf: 628 ppct: 8 formats: tig: atl: Increased Intrasubject Variability in Response Time in Youths With Bipolar Disorder and At-Risk Family Members. aug: au: Brotman, Melissa A. Rooney, Melissa H. Skup, Martha Pine, Daniel S. Leibenluft, Ellen su: Phenotypes Attention Genetics of bipolar disorder Mental illness Youth sug: subj: Phenotypes Attention Genetics of bipolar disorder Mental illness Youth keyword: Genotype and phenotype ab: Objective: Deficits in sustained attention may represent an endophenotype for bipolar disorder (BD). One heritable measure of sustained attention is intrasubject variability in response time (ISV-RT). We tested the hypothesis that, compared with controls, both youths with BD and those at familial risk for the disorder would have increased ISV-RT. Method: Subjects were 28 patients with BD, 26 unaffected youths with a first-degree relative with BD, and 24 control youths without an affected relative, all aged 7 to 17 years; Subjects completed the Flanker Continuous Performance Test. Results: Bipolar disorder and at-risk youths had increased ISV-RT, compared with the controls. Differences were independent of comorbid psychopathology in youths with BD and present in psychiatrically healthy at-risk youths. Conclusions: Increased ISV-RT may be a risk marker for BD. Further research is needed to investigate the neural and genetic underpinnings of this deficit, as well as the specificity of the finding to BD. J. Am. Acad. Child Adolesc. Psychiatry, 2009;48(6):628-635. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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