Motor Maps, Seizures, and Behaviour.
Atypically organised motor maps have been described in some people with epilepsy and we have modelled this in rats. Our goal is to more fully understand the mechanisms responsible for seizure-induced functional brain reorganisation and to reverse their effects. Here we present an overview- of the re...
| Publicado en: | Canadian Journal of Experimental Psychology Vol. 62; no. 2; pp. 132 - 140 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Artículo |
| Publicado: |
Canadian Psychological Association
June 2008
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=510814927&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 510814927 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 11961961 CJX jtl: Canadian Journal of Experimental Psychology issn: 11961961 maglogo: N pubinfo: dt: June 2008 vid: 62 iid: 2 pid: 98 pub: Canadian Psychological Association artinfo: ui: 510814927 10.1037/1196-1961.62.2.132 ppf: 132 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P size: 2.7MB tig: atl: Motor Maps, Seizures, and Behaviour. aug: au: Teskey, G. Campbell Monfils, Marie H. Flynn, Corey Young, Nicole A. Van Rooyen, Francine Henry, Luke C. Ozen, Lana J. Henderson, Amy K. Reid, Aylin Y. Brown, Andrew R. su: Animal models in epilepsy research Laboratory rats Brain function localization Cerebral cortex sug: subj: Animal models in epilepsy research Laboratory rats Brain function localization Cerebral cortex ab: Atypically organised motor maps have been described in some people with epilepsy and we have modelled this in rats. Our goal is to more fully understand the mechanisms responsible for seizure-induced functional brain reorganisation and to reverse their effects. Here we present an overview- of the relationship between neocortical motor maps, seizures, and interictal behaviour. To begin we summarise the observations of atypical motor maps with epilepsy and in animal models following experimentally induced seizures. Our novel experiments have established that motor map expansion is linked to a functional alteration of motor behaviour. Evidence for some of the putative brain mechanisms responsible for motor map size is discussed. Our successes reversing seizure-induced map expansion by two different methods are also briefly reviewed. Lastly, unanswered questions for possible future experimentation are posed. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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