Healthy Adolescents' Neural Response to Reward: Associations With Puberty, Positive Affect, and Depressive Symptoms.
Objective: Changes in reward-related behavior are an important component of normal adolescent affective development. Understanding the neural underpinnings of these normative changes creates a foundation for investigating adolescence as a period of vulnerability to affective disorders, substance use...
| Publicado en: | Journal of the American Academy of Child & Adolescent Psychiatry Vol. 49; no. 2; pp. 162 - 173 |
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| Autores principales: | , , , , , , , , |
| Formato: | Artículo |
| Publicado: |
Elsevier Science
February 2010
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=510973013&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 510973013 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 08908567 JAM jtl: Journal of the American Academy of Child & Adolescent Psychiatry issn: 08908567 maglogo: N pubinfo: dt: February 2010 vid: 49 iid: 2 pid: 467 pub: Elsevier Science artinfo: ui: 510973013 10.1097/00004583-201002000-00010 ppf: 162 ppct: 11 formats: tig: atl: Healthy Adolescents' Neural Response to Reward: Associations With Puberty, Positive Affect, and Depressive Symptoms. aug: au: Forbes, Erika E. Ryan, Neal D. Phillips, Mary L. Manuck, Stephen B. Worthman, Carol M. Moyles, Donna L. Tarr, Jill A. Sciarrillo, Samantha R. Dahl, Ronald E. su: Puberty Reward (Psychology) Developmental psychology Magnetic resonance imaging Brain function localization Adolescent psychology sug: subj: Puberty Reward (Psychology) Developmental psychology Magnetic resonance imaging Brain function localization Adolescent psychology ab: Objective: Changes in reward-related behavior are an important component of normal adolescent affective development. Understanding the neural underpinnings of these normative changes creates a foundation for investigating adolescence as a period of vulnerability to affective disorders, substance use disorders, and health problems. Studies of reward-related brain function have revealed conflicting findings regarding developmental change in the reactivity of the striatum and medial prefrontal cortex (mPFC) and have not considered puberty. The current study focused on puberty-specific changes in brain function and their association with mood. Method: A sample of 77 healthy adolescents (26 pre-/early pubertal, 51 mid-/late pubertal) recruited in a narrow age range (mean = 11.94 years, SD = 0.75) were assessed for sexual maturation and circulating testosterone, completed a functional magnetic resonance imaging (fMRI) guessing task with monetary reward, and underwent experience sampling of mood in natural environments. For comparison, 19 healthy adults completed the fMRI assessment. Results: Adolescents with more advanced pubertal maturation exhibited less striatal and more mPFC reactivity during reward outcome than similarly aged adolescents with less advanced maturation. Testosterone was positively correlated with striatal reactivity in boys during reward anticipation and negatively correlated with striatal reactivity in girls and boys during reward outcome. Striatal reactivity was positively correlated with real-world subjective positive affect and negatively correlated with depressive symptoms. mPFC reactivity was positively correlated with depressive symptoms. Conclusions: Reward-related brain function changes with puberty and is associated with adolescents' positive affect and depressive symptoms. Increased reward-seeking behavior at this developmental point could serve to compensate for these changes. J. Am. Acad. Child Adolesc. Psychiatry, 2010;49(2): 162–172. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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