Grasping Behavior in Schizophrenia Suggests Selective Impairment in the Dorsal Visual Pathway.
This study frames anomalous functional brain organization in schizophrenia (SCZ) within an evolutionary model of brain development, the dual trends theory (DTT). The DTT argues that neural architecture develops along 2 separate pathways: the dorsal archicortical trend and the ventral paleocortical t...
| Published in: | Journal of Abnormal Psychology Vol. 117; no. 4; pp. 799 - 812 |
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| Main Authors: | , , |
| Format: | Article |
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American Psychological Association
November 2008
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| Subjects: | |
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=511422481&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 511422481 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 0021843X JAP jtl: Journal of Abnormal Psychology issn: 0021843X maglogo: N pubinfo: dt: November 2008 vid: 117 iid: 4 pid: 34 pub: American Psychological Association artinfo: ui: 511422481 10.1037/a0013500 ppf: 799 ppct: 13 formats: tig: atl: Grasping Behavior in Schizophrenia Suggests Selective Impairment in the Dorsal Visual Pathway. aug: au: King, Jelena P. Christensen, Bruce K. Westwood, David A. su: Brain function localization Schizophrenia Brain -- Abnormalities sug: subj: Brain function localization Schizophrenia Brain -- Abnormalities ab: This study frames anomalous functional brain organization in schizophrenia (SCZ) within an evolutionary model of brain development, the dual trends theory (DTT). The DTT argues that neural architecture develops along 2 separate pathways: the dorsal archicortical trend and the ventral paleocortical trend. The DTT dovetails with visual system organization, which is also composed of 2 independent pathways: a dorsal stream dedicated to visuomotor action and a ventral stream dedicated to perceptual processing. The present study examined the integrity of these pathways using a size-contrast visual illusion. Prior research has shown that, normally, perceptual estimations of object size are susceptible to visual illusions, whereas goal-directed actions are resistant. The authors hypothesized that, unlike control participants, SCZ patients' actions would be susceptible to the illusion, reflecting dorsal stream dysfunction. Here, 42 SCZ patients and 42 healthy controls grasped and estimated the size of target blocks in control and illusion conditions. During estimation, both groups were equally perturbed by the illusion; however, grasping movements of patients alone were influenced by the illusion. These results suggest disrupted dorsal brain circuitry in SCZ but relatively intact ventral circuitry. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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