Cognition and white matter hyperintensities in older depressed patients.
Objective: The authors compared amounts of white matter hyperintensity in late- and early-onset depressed patients and never-depressed older subjects, compared neuropsychological function in these groups, and investigated the association between white matter hyperintensities and cognitive function...
| Publicado en: | American Journal of Psychiatry Vol. 153; pp. 1280 - 1288 |
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| Autores principales: | , , |
| Formato: | Artículo |
| Publicado: |
American Psychiatric Publishing, Inc.
October 1996
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=512859561&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 512859561 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 0002953X API jtl: American Journal of Psychiatry issn: 0002953X maglogo: N pubinfo: dt: October 1996 vid: 153 pid: 37323 pub: American Psychiatric Publishing, Inc. artinfo: ui: 512859561 ppf: 1280 ppct: 8 formats: tig: atl: Cognition and white matter hyperintensities in older depressed patients. aug: au: Lesser, Ira M. Boone, Kyle B. Mehringer, C. Mark su: Older people with mental illness Mental depression Cognition Brain -- Abnormalities sug: subj: Older people with mental illness Mental depression Cognition Brain -- Abnormalities ab: Objective: The authors compared amounts of white matter hyperintensity in late- and early-onset depressed patients and never-depressed older subjects, compared neuropsychological function in these groups, and investigated the association between white matter hyperintensities and cognitive function in depression. Method: Sixty currently depressed patients whose first depression occurred after age 50 years, 35 depressed patients over age 50 whose first depression occurred before age 35, and 165 nonpsychiatrically ill subjects over age 50 underwent magnetic resonance imaging (MRI) and neuropsychological evaluation. Areas of white matter hyperintensity were measured from MRI images. Results: The late-onset patients had more white matter hyperintensity than either of the other groups. Compared to the nondepressed subjects, the patients had significantly lower scores in the cognitive domains of nonverbal intelligence, nonverbal memory, constructional ability, executive ability, and information processing speed. The cognitive abnormalities were mostly confined to the late-onset patients, and the presence of a large amount of white matter hyperintensity was associated with significantly poorer executive skills. However, most of the scores were not in the significantly impaired range. Conclusions: Large amounts of white matter hyperintensity are more frequent in patients with late-onset depression than in elderly subjects with early-onset or no depression. Both late- and early-onset elderly depressed patients show mild decrements in some “right hemisphere” cognitive skills; the late-onset subjects also show deterioration in information processing speed and executive functions. Patients with large amounts of white matter hyperintensity have significantly poorer executive function. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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