High vesicular monoamine transporter binding in asyptomatic bipolor I disorder: sex differences and cognitive correlates.
|WbObjective:[|WB] It has been hypothesized that anomalies in monoaminergic function underlie some of the manifestations of bipolar disorder. In this study the authors examined the possibility that trait-related abnormalities in the concentration of monoaminergic synaptic terminals may be present...
| Publicado en: | American Journal of Psychiatry Vol. 157; no. 10; pp. 1619 - 1629 |
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| Autores principales: | , , |
| Formato: | Artículo |
| Publicado: |
American Psychiatric Publishing, Inc.
October 2000
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=513024615&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 513024615 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 0002953X API jtl: American Journal of Psychiatry issn: 0002953X maglogo: N pubinfo: dt: October 2000 vid: 157 iid: 10 pid: 37323 pub: American Psychiatric Publishing, Inc. artinfo: ui: 513024615 10.1176/appi.ajp.157.10.1619 ppf: 1619 ppct: 10 formats: tig: atl: High vesicular monoamine transporter binding in asyptomatic bipolor I disorder: sex differences and cognitive correlates. aug: au: Zubieta, Jon-Kar Huguelet, Philippe Ohl, Linda E. su: Bipolar disorder Amines Gender differences (Psychology) Brain function localization sug: subj: Bipolar disorder Amines Gender differences (Psychology) Brain function localization ab: |WbObjective:[|WB] It has been hypothesized that anomalies in monoaminergic function underlie some of the manifestations of bipolar disorder. In this study the authors examined the possibility that trait-related abnormalities in the concentration of monoaminergic synaptic terminals may be present in patients with asymptomatic bipolar disorder type I. |WbMethod:[|WB] The concentration of a stable presynaptic marker, the vesicular monoamine transporter protein (VMAT2), was quantified with (+){11C}dihydrotetrabenazine (DTBZ) and positron emission tomography. Sixteen asymptomatic patients with bipolar I disorder who had a prior history of mania with psychosis (nine men and seven women) and individually matched healthy subjects were studied. Correlational analyses were conducted to examine the relationship between regional VMAT2 binding, cognitive function, and clinical variables. |WbResults:[|WB] VMAT2 binding in the thalamus and ventral brainstem of the bipolar patients was higher than that in the comparison subjects. VMAT2 concentrations in these regions correlated with performance on measures of frontal, executive function. In addition, sex differences in VMAT2 binding were detected in the thalamus of the bipolar patients; the male patients had higher binding than the women. No sex differences in binding were observed in the healthy comparison group. |WbConclusions:[|WB] These initial results suggest that higher than normal VMAT2 expression and, by extension, concentration of monoaminergic synaptic terminals, may represent a trait-related abnormality in patients with bipolar I disorder and that male and female patients show different patterns. Also, VMAT2 concentrations may be associated with some of the cognitive deficits encountered in euthymic bipolar disorder. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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