Elevation in late-life depression of intercellular adhesion of molecule-1 expression in the dorsolateral prefrontal cortex.
|WbObjective:[|WB] Late-life depression may be associated with vascular disease. The authors investigated this association by determining whether intercellular adhesion molecule-1 (ICAM-1), a marker of ischemia-induced inflammation, is elevated in the dorsolateral prefrontal cortex in depression....
| Publicado en: | American Journal of Psychiatry Vol. 157; no. 10; pp. 1682 - 1685 |
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| Autores principales: | , , |
| Formato: | Artículo |
| Publicado: |
American Psychiatric Publishing, Inc.
October 2000
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=513024630&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 513024630 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 0002953X API jtl: American Journal of Psychiatry issn: 0002953X maglogo: N pubinfo: dt: October 2000 vid: 157 iid: 10 pid: 37323 pub: American Psychiatric Publishing, Inc. artinfo: ui: 513024630 10.1176/appi.ajp.157.10.1682 ppf: 1682 ppct: 3 formats: tig: atl: Elevation in late-life depression of intercellular adhesion of molecule-1 expression in the dorsolateral prefrontal cortex. aug: au: Thomas, Alan J. Ferrier, I. Nicol Kalaria, Rajesh N. su: Mental depression Frontal lobe Older people with mental illness Cerebrovascular disease sug: subj: Mental depression Frontal lobe Older people with mental illness Cerebrovascular disease ab: |WbObjective:[|WB] Late-life depression may be associated with vascular disease. The authors investigated this association by determining whether intercellular adhesion molecule-1 (ICAM-1), a marker of ischemia-induced inflammation, is elevated in the dorsolateral prefrontal cortex in depression. |WbMethod:[|WB] The authors studied postmortem tissue from 20 depressed subjects and a matched comparison group of 20 nondepressed subjects. They used immunocytochemistry to stain ICAM-1 in blood vessels on sections of the dorsolateral prefrontal cortex and occipital cortex and quantitative true color image analysis to measure the proportion of vessels expressing ICAM-1. |WbResults:[|WB] ICAM-1 was significantly higher in both the gray and white matter of the depressed subjects' dorsolateral prefrontal cortex than the comparison subjects' dorsolateral prefrontal cortex. The difference between these groups was much smaller in the gray and white matter of the occipital cortex. |WbConclusions:[|WB] These findings support the vascular depression hypothesis, which has important implications for the understanding and management of late-life depression. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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