Cytokine production in patients with anorexia nervosa, bulimia nervosa, and obesity.
|WbObjective:[|WB] We previously reported elevated serum levels of the cytokines interleukin-6 (IL-6) and transforming growth factor-β (TGF-β) in patients with anorexia nervosa (AN). We investigated the cellular production of these two cytokines and of interferon-γ (IFN-γ), interleukin-1α (IL-1α),...
| Publicado en: | International Journal of Eating Disorders Vol. 28; no. 3; pp. 293 - 303 |
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| Autores principales: | , , |
| Formato: | Artículo |
| Publicado: |
John Wiley & Sons, Inc.
November 2000
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=513035962&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 513035962 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 02763478 IJD jtl: International Journal of Eating Disorders issn: 02763478 maglogo: N pubinfo: dt: November 2000 vid: 28 iid: 3 pid: 62151 pub: John Wiley & Sons, Inc. artinfo: ui: 513035962 10.1002/1098-108X(200011)28:3<293::AID-EAT6>3.0.CO;2-F ppf: 293 ppct: 10 formats: tig: atl: Cytokine production in patients with anorexia nervosa, bulimia nervosa, and obesity. aug: au: Raymond, Nancy C. Dysken, Maurice Bettin, Kris su: Cytokines Anorexia nervosa Bulimia Obesity sug: subj: Cytokines Anorexia nervosa Bulimia Obesity ab: |WbObjective:[|WB] We previously reported elevated serum levels of the cytokines interleukin-6 (IL-6) and transforming growth factor-β (TGF-β) in patients with anorexia nervosa (AN). We investigated the cellular production of these two cytokines and of interferon-γ (IFN-γ), interleukin-1α (IL-1α), and tumor necrosis factor-α (TNF-α) in subjects with AN, bulimia nervosa (BN), and obesity as well as in normal-weight control subjects. |WbMethods:[|WB] Supernatant fluids from isolated peripheral blood mononuclear cells (PBMC) incubated with and without concanavalin A (ConA) were assayed for cytokine concentrations by enzyme-linked immunosorbent assay (ELISA). |WbResults:[|WB] Significant differences across the four groups were found in the stimulated cellular production of IFN-γ and IL-6. Stimulated IFN-γ production was elevated in the AN roup compared to controls. IL-6 production was significantly elevated in obese subjects relative to the two normal-weight groups, BN and controls, and tended to be higher in the AN group than in the controls, but not significantly so. IL-1α production was greater in obese subjects. |WbConclusion:[|WB] The findings of increased IFN-γ production and a tendency toward increased IL-6 production (both of which suppress food intake in animals) in individuals who severely restrict food intake suggest a potential role for these cytokines in the pathogenesis of AN. Elevated IL-6 and IL-1α production by PBMC in obese individuals requires further investigation to determine if these cytokines contribute to the development or perpetuation of obesity. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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