Subcortical correlates of craving in recently abstinent alcoholic patients.
Objective: This study investigated functional cerebral correlates of craving in alcoholic patients and examined the state/trait characteristics of the regional cerebral network implicated in craving. Method: Functional magnetic resonance imaging (fMRI) was used to map cerebral response elicited by e...
| Publicado en: | American Journal of Psychiatry Vol. 158; no. 7; pp. 1075 - 1084 |
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| Autores principales: | , , |
| Formato: | Artículo |
| Publicado: |
American Psychiatric Publishing, Inc.
July 2001
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=513041405&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 513041405 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 0002953X API jtl: American Journal of Psychiatry issn: 0002953X maglogo: N pubinfo: dt: July 2001 vid: 158 iid: 7 pid: 37323 pub: American Psychiatric Publishing, Inc. artinfo: ui: 513041405 10.1176/appi.ajp.158.7.1075 ppf: 1075 ppct: 9 formats: tig: atl: Subcortical correlates of craving in recently abstinent alcoholic patients. aug: au: Schneider, Frank Habel, Ute Wagner, Michael su: Desire Alcoholism Temperance Brain function localization Alcohol Psychology sug: subj: Desire Alcoholism Temperance Brain function localization Alcohol Psychology ab: Objective: This study investigated functional cerebral correlates of craving in alcoholic patients and examined the state/trait characteristics of the regional cerebral network implicated in craving. Method: Functional magnetic resonance imaging (fMRI) was used to map cerebral response elicited by ethanol odor in 10 male patients with alcohol dependence who had undergone detoxification and 10 matched nonpatients. After 3 weeks, during which the patients underwent standardized behavioral therapy with psychopharmacological intervention, all subjects were studied a second time with fMRI to evaluate the effects of therapy on the functional cerebral correlates of craving. Results: In the alcoholic patients, cue-in-duced craving before treatment elicited activation primarily in the subcortical-limbic region of the right amygdala/hippocampal area and in the cerebellum. After treatment, activation was found in the superior temporal sulcus, while subcortical or cerebellar participation was no longer present. Comparison subjects showed no comparable amygdala or cerebellar activation during ethanol stimulation and demonstrated no change in activation pattern between measurements. Conclusions: This investigation points to state-dependent neurobiological correlates of cue-induced craving in alcoholic patients and suggests that these correlates can be influenced by therapeutic interventions. The presence of emotional aspects of craving is suggested by amygdala activation. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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