Working and Long-Term Memory Deficits in Schizophrenia: Is There a Common Prefrontal Mechanism?
This study tested the hypothesis that dorsolateral prefrontal cortex deficits contribute to both working memory and long-term memory disturbances in schizophrenia. It also examined whether such deficits were more severe for verbal than nonverbal stimuli. Functional magnetic resonance imaging was use...
| Publicado en: | Journal of Abnormal Psychology Vol. 111; no. 3; pp. 478 - 495 |
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| Autores principales: | , , |
| Formato: | Artículo |
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American Psychological Association
August 2002
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=513147795&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 513147795 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 0021843X JAP jtl: Journal of Abnormal Psychology issn: 0021843X maglogo: N pubinfo: dt: August 2002 vid: 111 iid: 3 pid: 34 pub: American Psychological Association artinfo: ui: 513147795 10.1037/0021-843X.111.3.478 ppf: 478 ppct: 17 formats: tig: atl: Working and Long-Term Memory Deficits in Schizophrenia: Is There a Common Prefrontal Mechanism? aug: au: Barch, Deanna M. Csernansky, John G. Conturo, Tom su: Long-term memory Short-term memory Schizophrenia Brain function localization sug: subj: Long-term memory Short-term memory Schizophrenia Brain function localization ab: This study tested the hypothesis that dorsolateral prefrontal cortex deficits contribute to both working memory and long-term memory disturbances in schizophrenia. It also examined whether such deficits were more severe for verbal than nonverbal stimuli. Functional magnetic resonance imaging was used to assess cortical activation during performance of verbal and nonverbal versions of a working memory task and both encoding and recognition tasks in 38 individuals with schizophrenia and 48 healthy controls. Performance of both working memory and long-term memory tasks revealed disturbed dorsolateral prefrontal cortex activation in schizophrenia, although medial temporal deficits were also present. Some evidence was found for more severe cognitive and functional deficits with verbal than nonverbal stimuli, although these results were mixed. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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