Sex Differences in Functional Connectivity in First Episode and Chronic Schizophrenia Patients.
Objective: There has been consistent evidence for a lower incidence and milder course of schizophrenia in women, yet there have been very few investigations of sex differences in brain function in this disorder. This study used a new high-temporal-resolution measure of functional brain connectivity...
| Publicado en: | American Journal of Psychiatry Vol. 161; no. 9; pp. 1595 - 1603 |
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| Autores principales: | , , |
| Formato: | Artículo |
| Publicado: |
American Psychiatric Publishing, Inc.
September 2004
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=513173200&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 513173200 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 0002953X API jtl: American Journal of Psychiatry issn: 0002953X maglogo: N pubinfo: dt: September 2004 vid: 161 iid: 9 pid: 37323 pub: American Psychiatric Publishing, Inc. artinfo: ui: 513173200 10.1176/appi.ajp.161.9.1595 ppf: 1595 ppct: 8 formats: tig: atl: Sex Differences in Functional Connectivity in First Episode and Chronic Schizophrenia Patients. aug: au: Slewa-Younan, Shameran Gordon, Evian Harris, Anthony W. su: Brain function localization Electroencephalography Schizophrenia Gender differences (Psychology) sug: subj: Brain function localization Electroencephalography Schizophrenia Gender differences (Psychology) ab: Objective: There has been consistent evidence for a lower incidence and milder course of schizophrenia in women, yet there have been very few investigations of sex differences in brain function in this disorder. This study used a new high-temporal-resolution measure of functional brain connectivity to test the prediction that female patients would show relatively greater inter- and intrahemispheric connectivity than male patients, particularly in the early stage of schizophrenia. Method: Forty patients with chronic schizophrenia (20 women and 20 men) and 24 patients with first-episode schizophrenia (12 women and 12 men) and their respective matched comparison groups completed a conventional auditory oddball task. Phase synchronous gamma (40 Hz) activity was extracted from EEG recording during the task and time-locked to the oddball (target) stimuli. Results: Chronic schizophrenia subjects showed a reduction in global functional connectivity (lower gamma phase synchrony) relative to their matched healthy subjects. Unexpectedly, this reduction was most apparent in female patients. By contrast, while first-episode patients showed a general reduction in the speed of frontal connectivity, the speed of global connectivity was relatively faster in female patients. Conclusions: This is the first study to investigate sex differences in schizophrenia that used the functional connectivity measure of gamma phase synchrony. The results suggest that in female patients with schizophrenia, additional breakdowns in brain network connectivity may develop with illness chronicity. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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