Cerebellar, Prefrontal Cortex, and Thalamic Volumes Over Two Time Points in Adolescent-Onset Schizophrenia.
Objective: Structural and functional studies implicate multiple brain lesions as a basis for a functional dysconnectivity underlying the cognitive and symptom profiles in schizophrenia. The aim of this study was to examine the hypothesis that early-onset schizophrenia is associated with structural a...
| Publicado en: | American Journal of Psychiatry Vol. 161; no. 6; pp. 1023 - 1030 |
|---|---|
| Autores principales: | , , |
| Formato: | Artículo |
| Publicado: |
American Psychiatric Publishing, Inc.
June 2004
|
| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=513178001&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 513178001 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 0002953X API jtl: American Journal of Psychiatry issn: 0002953X maglogo: N pubinfo: dt: June 2004 vid: 161 iid: 6 pid: 37323 pub: American Psychiatric Publishing, Inc. artinfo: ui: 513178001 10.1176/appi.ajp.161.6.1023 ppf: 1023 ppct: 7 formats: tig: atl: Cerebellar, Prefrontal Cortex, and Thalamic Volumes Over Two Time Points in Adolescent-Onset Schizophrenia. aug: au: James, Anthony C. James, Susan Smith, David M. su: Brain -- Abnormalities Schizophrenia Youth with mental illness sug: subj: Brain -- Abnormalities Schizophrenia Youth with mental illness ab: Objective: Structural and functional studies implicate multiple brain lesions as a basis for a functional dysconnectivity underlying the cognitive and symptom profiles in schizophrenia. The aim of this study was to examine the hypothesis that early-onset schizophrenia is associated with structural abnormalities in the prefrontal cortex, thalamus, and cerebellum, compatible with a dysconnectivity syndrome. Method: Two magnetic resonance imaging scans of 16 patients and 16 normal comparison subjects were undertaken on average 2 to 3 years apart. The participants were all from a defined geographic area in the United Kingdom with a population of 2.5 million. Results: In comparison to the normal adolescents, the schizophrenic subjects demonstrated low prefrontal cortex and thalamic volumes. The relatively large difference in prefrontal and thalamic volumes in these adolescents with schizophrenia implies a more severe disease process than in adult subjects. Conclusions: The thalamic and frontal lobe findings provide preliminary, supportive structural evidence for a neurodevelopmental basis for a dysconnectivity syndrome, although the cerebellar findings were inconclusive. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
|---|