Neural Circuitry Engaged During Unsuccessful Motor Inhibition in Pediatric Bipolar Disorder.
Objective: Deficits in motor inhibition may contribute to impulsivity and irritability in children with bipolar disorder. Studies of the neural circuitry engaged during failed motor inhibition in pediatric bipolar disorder may increase our understanding of the pathophysiology of the illness. The aut...
| Publicado en: | American Journal of Psychiatry Vol. 164; no. 1; pp. 52 - 61 |
|---|---|
| Autores principales: | , , , , , , , , , , , |
| Formato: | Artículo |
| Publicado: |
American Psychiatric Publishing, Inc.
January 2007
|
| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=513187442&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 513187442 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 0002953X API jtl: American Journal of Psychiatry issn: 0002953X maglogo: N pubinfo: dt: January 2007 vid: 164 iid: 1 pid: 37323 pub: American Psychiatric Publishing, Inc. artinfo: ui: 513187442 10.1176/appi.ajp.164.1.52 ppf: 52 ppct: 9 formats: tig: atl: Neural Circuitry Engaged During Unsuccessful Motor Inhibition in Pediatric Bipolar Disorder. aug: au: Leibenluft, Ellen Rich, Brendan A. Vinton, Deborah T. Nelson, Eric E. Fromm, Stephen J. Berghorst, Lisa H. Joshi, Paramjit Robb, Adelaide Schachar, Russell J. Dickstein, Daniel P. McClure, Erin B. Pine, Daniel S. su: Bipolar disorder in children Attention-deficit hyperactivity disorder Response inhibition Motor ability Child behavior Children with mental illness sug: subj: Bipolar disorder in children Attention-deficit hyperactivity disorder Response inhibition Motor ability Child behavior Children with mental illness ab: Objective: Deficits in motor inhibition may contribute to impulsivity and irritability in children with bipolar disorder. Studies of the neural circuitry engaged during failed motor inhibition in pediatric bipolar disorder may increase our understanding of the pathophysiology of the illness. The authors tested the hypothesis that children with bipolar disorder and comparison subjects would differ in ventral prefrontal cortex, striatal, and anterior cingulate activation during unsuccessful motor inhibition. They also compared activation in medicated versus unmedicated children with bipolar disorder and in children with bipolar disorder and attention deficit hyperactivity disorder (ADHD) versus those with bipolar disorder without ADHD. Method: The authors conducted an event-related functional magnetic resonance imaging study comparing neural activation in children with bipolar disorder and healthy comparison subjects while they performed a motor inhibition task. The study group included 26 children with bipolar disorder (13 unmedicated and 15 with ADHD) and 17 comparison subjects matched by age, gender, and IQ. Results: On failed inhibitory trials, comparison subjects showed greater bilateral striatal and right ventral prefrontal cortex activation than did patients. These deficits were present in unmedicated patients, but the role of ADHD in mediating them was unclear. Conclusions: In relation to comparison subjects, children with bipolar disorder may have deficits in their ability to engage striatal structures and the right ventral prefrontal cortex during unsuccessful inhibition. Further research should ascertain the contribution of ADHD to these deficits and the role that such deficits may play in the emotional and behavioral dysregulation characteristic of bipolar disorder. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
|---|