Communication between the Zinc and Nickel Sites in Dimeric HypA: Metal Recognition and pH Sensing.

Helicobacter pylori, a pathogen that colonizes the human stomach, requires the nickel-containing metalloenzymes urease and NiFe-hydrogenase to survive this low pH environment. The maturation of both enzymes depends on the metallochaperone, HypA. HypA contains two metal sites, an intrinsic zinc site...

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Bibliographic Details

Published in:	Journal of the American Chemical Society Vol. 132; no. 30; pp. 10338 - 10352
Main Authors:	Herbst, Robert W., Perovic, Iva, Martin-Diaconescu, Vlad, O'Brien, Kerrie, Chivers, Peter T., Pochapsky, Susan Sondej, Pochapsky, Thomas C., Maroney, Michael J.
Format:	Article
Published:	American Chemical Society 8/4/2010
Subjects:	Helicobacter pylori Hydrogen-ion concentration Zinc Nickel Metalloenzymes Nuclear magnetic resonance spectroscopy Hydrogenase
Online Access:	View this record in EBSCOhost