Membrane Disk and Sphere: Controllable Mesoscopic Structures for the Capture and Release of a Targeted Object.
Design of molecules for self-assembled mesoscopic structures with specific functions is an important and interesting challenge that spans across disciplines such as nanosciences. A closed lipid membrane is a good example of a self-assembled mesostructure. In this study, we developed controllable mem...
| Publicado en: | Journal of the American Chemical Society Vol. 132; no. 30; pp. 10528 - 10533 |
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| Autores principales: | , , , , |
| Formato: | Artículo |
| Publicado: |
American Chemical Society
8/4/2010
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=hlh&AN=52799918&site=ehost-live header: @attributes: shortDbName: hlh uiTerm: 52799918 longDbName: Humanities International Complete uiTag: AN controlInfo: bkinfo: jinfo: jid: 00027863 ACS jtl: Journal of the American Chemical Society issn: 00027863 maglogo: N pubinfo: dt: 8/4/2010 vid: 132 iid: 30 pid: 997 pub: American Chemical Society artinfo: ui: 52799918 10.1021/ja103895b ppf: 10528 ppct: 5 formats: tig: atl: Membrane Disk and Sphere: Controllable Mesoscopic Structures for the Capture and Release of a Targeted Object. aug: au: Hamada, Tsutomu Sugimoto, Ryoko Vestergaard, Mun'delanji C. Nagasaki, Takeshi Takagi, Masahiro affil: School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi, Ishikawa 923-1292, Japan Graduate School of Engineering, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan su: Computer-assisted molecular design Nanoscience Molecular structure Bilayer lipid membranes Particles Wiener processes Microencapsulation Microreactors sug: subj: Computer-assisted molecular design Nanoscience Molecular structure Bilayer lipid membranes Particles Wiener processes Microencapsulation Microreactors ab: Design of molecules for self-assembled mesoscopic structures with specific functions is an important and interesting challenge that spans across disciplines such as nanosciences. A closed lipid membrane is a good example of a self-assembled mesostructure. In this study, we developed controllable membrane formation by making a subtle change at the molecular level. We utilized a synthetic photosensitive amphiphile (KAON12) to achieve the photobased molecular manipulation of the opening and closing of membranes through reversible transitions between sphere and disk structures. We found that the mechanism is based on the photoswitching of the membrane line tension, as deduced from the fluctuation of the membrane edge, through the action of KAON12. Furthermore, we demonstrated the controllable capture and release of colloidal particles into and from a membrane sphere. The observation of Brownian motion of the particle confirmed colloidal encapsulation. This successful photomanipulation of mesoscopic membrane structures in a noncontact and reversible manner should lead to a better understanding of the mechanism of membrane self-organization and may see wider application, such as in microreactors and drug-delivery systems. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y dt: @attributes: year: 2010 holdings: @attributes: islocal: N |
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