Crystal Structure of Chiral γPNA with Complementary DNA Strand: Insights into the Stability and Specificity of Recognition and Conformational Preorganization.

We have determined the structure of a PNA-DNA duplex to 1.7 A resolution by multiple- wavelength anomalous diffraction phasing method on a zinc derivative. This structure represents the first high-resolution 3D view of a hybrid duplex containing a contiguous chiral PNA strand with complete γ-backbon...

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Bibliographic Details

Published in:	Journal of the American Chemical Society Vol. 132; no. 31; pp. 10717 - 10728
Main Authors:	Yeh, Joanne I., Shivachev, Boris, Rapireddy, Srinivas, Crawford, Matthew J., GiI, Roberto R., Du, Shoucheng, Madrid, Marcela, Ly, Danith H.
Format:	Article
Published:	American Chemical Society 8/11/2010
Subjects:	Chirality Antisense DNA Crystals Stability (Mechanics) Peptides Wavelengths Optical diffraction Nucleic acid hybridization
Online Access:	View this record in EBSCOhost