Saffron in the treatment of patients with mild to moderate Alzheimer’s disease: a 16-week, randomized and placebo-controlled trial.
What is known: Herbal medicines have been used in the treatment of behavioural and psychological symptoms of dementia but with variable response. Crocus sativus (saffron) may inhibit the aggregation and deposition of amyloid β in the human brain and may therefore be useful in Alzheimer’s disease (AD...
| Publicado en: | Journal of Clinical Pharmacy & Therapeutics Vol. 35; no. 5; pp. 581 - 589 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | clinical trial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Oct2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=53541375&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 53541375 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02694727 EV4 jtl: Journal of Clinical Pharmacy & Therapeutics issn: 02694727 maglogo: Y pubinfo: dt: Oct2010 vid: 35 iid: 5 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 53541375 105099228 105099228 10.1111/j.1365-2710.2009.01133.x 53541375 ppf: 581 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Saffron in the treatment of patients with mild to moderate Alzheimer’s disease: a 16-week, randomized and placebo-controlled trial. aug: au: Akhondzadeh, S. Sabet, M. Shafiee Harirchian, M. H. Togha, M. Cheraghmakani, H. Razeghi, S. Hejazi, S. Sh. Yousefi, M. H. Alimardani, R. Jamshidi, A. Zare, F. Moradi, A. affil: ‡Department of Neurology, Tehran University of Medical Sciences, Tehran sug: subj: Alzheimer's Disease Drug Therapy Plants, Medicinal Therapeutic Use Human Double-Blind Studies Alzheimer's Disease Physiopathology Iran Middle Age Aged Scales Psychological Tests Random Assignment Repeated Measures Analysis of Variance T-Tests Fisher's Exact Test Descriptive Statistics Male Female Alternative Therapies Funding Source Middle Aged: 45-64 years Aged: 65+ years Male Female ab: What is known: Herbal medicines have been used in the treatment of behavioural and psychological symptoms of dementia but with variable response. Crocus sativus (saffron) may inhibit the aggregation and deposition of amyloid β in the human brain and may therefore be useful in Alzheimer’s disease (AD). Objective: The goal of this study was to assess the efficacy of saffron in the treatment of mild to moderate AD. Methods: Forty-six patients with probable AD were screened for a 16-week, double-blind study of parallel groups of patients with mild to moderate AD. The psychometric measures, which included AD assessment scale-cognitive subscale (ADAS-cog), and clinical dementia rating scale-sums of boxes, were performed to monitor the global cognitive and clinical profiles of the patients. Patients were randomly assigned to receive capsule saffron 30 mg/day (15 mg twice per day) (Group A) or capsule placebo (two capsules per day) for a 16-week study. Results: After 16 weeks, saffron produced a significantly better outcome on cognitive function than placebo (ADAS-cog: F = 4·12, d.f. = 1, P = 0·04; CDR: F = 4·12, d.f. = 1, P = 0·04). There were no significant differences in the two groups in terms of observed adverse events. What is new and conclusion: This double-blind, placebo-controlled study suggests that at least in the short-term, saffron is both safe and effective in mild to moderate AD. Larger confirmatory randomized controlled trials are called for. pubtype: Academic Journal doctype: clinical trial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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