In Vitro and in Vivo Studies of FePt Nanoparticles for Dual Modal CT/MRI Molecular Imaging.
The water-solvable FePt nanoparticles of 3, 6, and 12 nm in diameter (3 nm-, 6 nm-, and 12 nm-FePt) were synthesized and applied as a dual modality contrast agent for CT/MRI molecular imaging. These nanoparticles present excellent biocompatibility and hemocompatibility in all test concentrations for...
| Publicado en: | Journal of the American Chemical Society Vol. 132; no. 38; pp. 13270 - 13279 |
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| Autores principales: | , , , , , |
| Formato: | Artículo |
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American Chemical Society
9/29/2010
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=hlh&AN=54273064&site=ehost-live header: @attributes: shortDbName: hlh uiTerm: 54273064 longDbName: Humanities International Complete uiTag: AN controlInfo: bkinfo: jinfo: jid: 00027863 ACS jtl: Journal of the American Chemical Society issn: 00027863 maglogo: N pubinfo: dt: 9/29/2010 vid: 132 iid: 38 pid: 997 pub: American Chemical Society artinfo: ui: 54273064 10.1021/ja1035013 ppf: 13270 ppct: 9 formats: tig: atl: In Vitro and in Vivo Studies of FePt Nanoparticles for Dual Modal CT/MRI Molecular Imaging. aug: au: Shang-Wei Chou Yu-Hong Shau Ping-Ching Wu Yu-Sang Yang Dar-Bin Shieh Chia-Chun Chen affil: Department of Chemistry, National Taiwan Normal University, Taipei 11677, Taiwan Institute of Oral Medicine and Department of Stomatology, National Cheng Kung University, Tainan 70101, Taiwan Institute of Basic Medical Sciences, National Cheng Kung University, Tainan 70101, Taiwan Advanced Optoelectronic Technology Center, National Cheng Kung University, Tainan 70101, Taiwan Center for Micro/Nano Science and Technology, National Cheng Kung University, Tainan 70101, Taiwan Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei 10617, Taiwan su: Nanoparticles Imaging systems Medical science equipment Tomography X-rays sug: subj: Nanoparticles Imaging systems Medical science equipment Tomography X-rays ab: The water-solvable FePt nanoparticles of 3, 6, and 12 nm in diameter (3 nm-, 6 nm-, and 12 nm-FePt) were synthesized and applied as a dual modality contrast agent for CT/MRI molecular imaging. These nanoparticles present excellent biocompatibility and hemocompatibility in all test concentrations for the imaging contrast. The biodistribution analysis revealed the highest serum concentration and circulation half-life for 12 nm-FePt, followed by 6 nm-FePt then 3 nm-FePt. Thus, the 3 nm-FePt showed higher brain concentrations. Anti-Her2 antibody conjugated FePt nanoparticles demonstrated molecular expression dependent CT/MRI dual imaging contrast effect in MBT2 cell line and its Her2/neu gene knock out counterpart. Selective contrast enhancement of Her2/neu overexpression cancer lesions in both CT and MRI was found in tumor bearing animal after tail vein injection of the nanoparticles. The 12 nm-FePt outperformed 3 nm-FePt in both imaging modalities. These results indicate the potential of FePt nanoparticles to serve as novel multimodal molecular imaging contrast agents in clinical settings. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y dt: @attributes: year: 2010 holdings: @attributes: islocal: N |
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