Activation and Effective Connectivity Changes Following Explicit-Memory Training for Face–Name Pairs in Patients With Mild Cognitive Impairment: A Pilot Study.
Background. Mild cognitive impairment (MCI) is often a precursor to Alzheimer disease. Little research has examined the efficacy of cognitive rehabilitation in patients with MCI, and the relevant neural mechanisms have not been explored. The authors previously showed the behavioral efficacy of cogni...
| Publicado en: | Neurorehabilitation & Neural Repair Vol. 25; no. 3; pp. 210 - 223 |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
Mar/Apr2011
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=60442074&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 60442074 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15459683 IRK jtl: Neurorehabilitation & Neural Repair issn: 15459683 maglogo: Y pubinfo: dt: Mar/Apr2011 vid: 25 iid: 3 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 60442074 104893297 104893297 10.1177/1545968310382424 60442074 ppf: 210 ppct: 13 formats: tig: atl: Activation and Effective Connectivity Changes Following Explicit-Memory Training for Face–Name Pairs in Patients With Mild Cognitive Impairment: A Pilot Study. aug: au: Hampstead, Benjamin M. Stringer, Anthony Y. Stilla, Randall F. Deshpande, Gopikrishna Xiaoping Hu Moore, Anna Bacon Sathian, K. affil: Rehabilitation R&D Center of Excellence, Atlanta VAMC, Decatur, Georgia sug: subj: Cognition Disorders Diagnosis Memory Evaluation Patient Care Methods Neurology Alzheimer's Disease Risk Factors Human Magnetic Resonance Imaging Methods Rehabilitation, Cognitive Methods Aging Memory Disorders Diagnostic Imaging Data Analysis Technology, Medical Analysis of Variance ab: Background. Mild cognitive impairment (MCI) is often a precursor to Alzheimer disease. Little research has examined the efficacy of cognitive rehabilitation in patients with MCI, and the relevant neural mechanisms have not been explored. The authors previously showed the behavioral efficacy of cognitive rehabilitation using mnemonic strategies for face–name associations in patients with MCI. Here, the authors used functional magnetic resonance imaging (fMRI) to test whether there were training-specific changes in activation and connectivity within memory-related areas. Methods. A total of 6 patients with amnestic, multidomain MCI underwent pretraining and posttraining fMRI scans, during which they encoded 90 novel face–name pairs and completed a 4-choice recognition memory test immediately after scanning. Patients were taught mnemonic strategies for half the face–name pairs during 3 intervening training sessions. Results. Training-specific effects comprised significantly increased activation within a widespread cerebral cortical network involving medial frontal, parietal, and occipital regions; the left frontal operculum and angular gyrus; and regions in the left lateral temporal cortex. Increased activation common to trained and untrained stimuli was found in a separate network involving inferior frontal, lateral parietal, and occipital cortical regions. Effective connectivity analysis using multivariate, correlation-purged Granger causality analysis revealed generally increased connectivity after training, particularly involving the middle temporal gyrus and foci in the occipital cortex and the precuneus. Conclusion. The authors’ findings suggest that the effectiveness of explicit-memory training in patients with MCI is associated with training-specific increases in activation and connectivity in a distributed neural system that includes areas involved in explicit memory. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|