Road Traffic and Childhood Leukemia: The ESCALE Study (SFCE).
BACKGROUND: Traffic is a source of environmental exposures, including benzene, which may be related to childhood leukemia. OBJECTIVES: A national registry-based case-control study [ESCALE (Etude Sur les Cancers et les Leucémies de l'Enfant, Study on Environmental and Genetic Risk Factors of Childhoo...
| Publicado en: | Environmental Health Perspectives Vol. 119; no. 4; pp. 566 - 573 |
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| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
National Institute of Environmental Health Sciences
Apr2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=60710074&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 60710074 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00916765 3B5 jtl: Environmental Health Perspectives issn: 00916765 maglogo: N pubinfo: dt: Apr2011 vid: 119 iid: 4 pid: 56539 pub: National Institute of Environmental Health Sciences place: Research Triangle Park, North Carolina artinfo: ui: 60710074 104709573 104709573 10.1289/ehp.1002429 60710074 ppf: 566 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Road Traffic and Childhood Leukemia: The ESCALE Study (SFCE). aug: au: Amigou, Alicia Sermage-Faure, Claire Orsi, Laurent Leverger, Guy Baruchel, André Bertrand, Yves Nelken, Brigitteÿ Robert, Alain Michel, Gérard Margueritte, Geneviève Perel, Yves Mechinaud, Françoise Bordigoni, Pierreÿ Hémon, Denis Clavel, Jacqueline affil: INSERM (Institut National de la Sant et de la Recherche Mdicale), CESP (Centre de recherche en Epidmiologie et Sant des Populations) Environmental Epidemiology of Cancer, Villejuif, France sug: subj: Leukemia Risk Factors Environmental Exposure Benzene Derivatives Adverse Effects Air Pollution Human Automobiles France Case Control Studies Child Adolescence Male Female Nitrogen Oxides Odds Ratio Regression Geographic Factors Structured Questionnaires Mothers Maximum Likelihood Data Analysis Software Child: 6-12 years Adolescent: 13-18 years Male Female ab: BACKGROUND: Traffic is a source of environmental exposures, including benzene, which may be related to childhood leukemia. OBJECTIVES: A national registry-based case-control study [ESCALE (Etude Sur les Cancers et les Leucémies de l'Enfant, Study on Environmental and Genetic Risk Factors of Childhood Cancers and Leukemia)] carried out in France was used to assess the effect of exposure to road traffic exhaust fumes on the risk of childhood leukemia. METHODS: Over the study period, 2003-2004, 763 cases and 1,681 controls < 15 years old were included, and the controls were frequency matched with the cases on age and sex. The ESCALE data were collected by a standardized telephone interview of the mothers. Various indicators of exposure to traffic and pollution were determined using the geocoded addresses at the time of diagnosis for the cases and of interview for the controls. Indicators of the distance from, and density of, main roads and traffic nitrogen dioxide (NO2) concentrations derived from traffic emission data were used. Odds ratios (ORs) were estimated using unconditional regression models adjusted for potential confounders. RESULTS: Acute leukemia (AL) was significantly associated with estimates of traffic NO2 concentration at the place of residence > 27.7 µg/m3 compared with NO2 concentration < 21.9 µg/m3 [OR = 1.2; confidence interval (CI), 1.0-1.5] and with the presence of a heavy-traffic road within 500 m compared with the absence of a heavy-traffic road in the same area (OR = 2.0; 95% CI, 1.0-3.6). There was a significant association between AL and a high density of heavy-traffic roads within 500 m compared with the reference category with no heavy-traffic road within 500 m (OR = 2.2; 95% CI, 1.1-4.2), with a significant positive linear trend of the association of AL with the total length of heavy-traffic road within 500m. CONCLUSION: This study supports the hypothesis that living close to heavy-traffic roads may increase the risk of childhood leukemia. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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