Continuous Flow Enzyme-Catalyzed Polymerization in a Microreactor.
Enzymes immobilized on solid supports are increasingly used for greener, more sustainable chemical transformation processes. Here, we used microreactors to study enzyme-catalyzed ring-opening polymerization of ϵ-caprolactone to polycaprolactone. A novel microreactor design enabled us to perform thes...
| Publicado en: | Journal of the American Chemical Society Vol. 133; no. 15; pp. 6006 - 6012 |
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| Autores principales: | , , , , , , |
| Formato: | Artículo |
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American Chemical Society
4/20/2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=hlh&AN=60793850&site=ehost-live header: @attributes: shortDbName: hlh uiTerm: 60793850 longDbName: Humanities International Complete uiTag: AN controlInfo: bkinfo: jinfo: jid: 00027863 ACS jtl: Journal of the American Chemical Society issn: 00027863 maglogo: N pubinfo: dt: 4/20/2011 vid: 133 iid: 15 pid: 997 pub: American Chemical Society artinfo: ui: 60793850 10.1021/ja111346c ppf: 6006 ppct: 6 formats: tig: atl: Continuous Flow Enzyme-Catalyzed Polymerization in a Microreactor. aug: au: Kundu, Santanu Bhangale, Atul S. Wallace, William E. Flynn, Kathleen M. Guttman, Charles M. Gross, Richard A. Beers, Kathryn L. affil: Polymers Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, United States Polytechnic Institute of NYU, Brooklyn, New York 11201, United States su: Enzymes Catalysts Polycaprolactone Polymerization Chemical reactions Microreactors sug: subj: Enzymes Catalysts Polycaprolactone Polymerization Chemical reactions Microreactors ab: Enzymes immobilized on solid supports are increasingly used for greener, more sustainable chemical transformation processes. Here, we used microreactors to study enzyme-catalyzed ring-opening polymerization of ϵ-caprolactone to polycaprolactone. A novel microreactor design enabled us to perform these heterogeneous reactions in continuous mode, in organic media, and at elevated temperatures. Using microreactors, we achieved faster polymerization and higher molecular mass compared to using batch reactors. While this study focused on polymerization reactions, it is evident that similar microreactor based platforms can readily be extended to other enzyme-based systems, for example, high-throughput screening of new enzymes and to precision measurements of new processes where continuous flow mode is preferred. This is the first reported demonstration of a solid supported enzyme-catalyzed polymerization reaction in continuous mode. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y dt: @attributes: year: 2011 holdings: @attributes: islocal: N |
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