The role of sampling in clinical trial design.

A treatment's recovery rate depends upon the percentage of clients who received the treatment and recovered. This rate is not logically interpretable as the personal probability of recovery of any individual client assigned to this treatment unless the rate is 0% or 100%. So clinical trials need to...

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Publicado en:Psychotherapy Research Vol. 21; no. 3; pp. 243 - 252
Autores principales: Krause, Merton, Lutz, Wolfgang, Boehnke, JanR.
Formato: Artículo
Publicado: Taylor & Francis Ltd May2011
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Acceso en línea:Ver este registro en EBSCOhost
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        atl: The role of sampling in clinical trial design.
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          Krause, Merton
          Lutz, Wolfgang
          Boehnke, JanR.
        affil: Clinical Psychology and Psychotherapy, Department of Psychology, University of Trier, Trier, Germany
      su:
        Clinical trials
        Medical experimentation on humans
        Aptitude-treatment interaction (Education)
        Sampling (Process)
        Probability theory
      sug:
        subj:
          Clinical trials
          Medical experimentation on humans
          Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology)
          Aptitude-treatment interaction (Education)
          Sampling (Process)
          Probability theory
      keyword:
        aptitude-treatment interaction research
        client sampling
        client-covariate sampling
        outcome research
        statistical methodology
        aptitude-treatment interaction research
        client sampling
        client-covariate sampling
        outcome research
        statistical methodology
      ab: A treatment's recovery rate depends upon the percentage of clients who received the treatment and recovered. This rate is not logically interpretable as the personal probability of recovery of any individual client assigned to this treatment unless the rate is 0% or 100%. So clinical trials need to be designed to help us learn how to distinguish before treatment the sorts of clients who recover in response to each available form of treatment from those who do not. This requires our developing sufficiently comprehensive sampling of clients and client covariates as part of the design of clinical trials, which would be more likely and efficiently achieved were there centralized programmatic planning and coordination of the development of these aspects of clinical trial design.
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      src: R
    language: English
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