The Need for Enzymatic Steering in Abietic Acid Biosynthesis: Gas-Phase Chemical Dynamics Simulations of Carbocation Rearrangements on a Bifurcating Potential Energy Surface.

Abietic acid, a constituent of pine resin, is naturally derived from abietadiene - a process that requires four enzymes: one (abietadiene synthase) for conversion of the acyclic, achiral geranylgeranyl diphosphate to the polycydic, chiral abietadiene (a complex process involving the copalyl diphosph...

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Bibliographic Details

Published in:	Journal of the American Chemical Society Vol. 133; no. 21; pp. 8335 - 8344
Main Authors:	Siebert, Matthew R., Jiaxu Zhang, Addepalli, Srirangam V., Tantillo, Dean J., Hase, William L.
Format:	Article
Published:	American Chemical Society 6/1/2011
Subjects:	Enzymatic analysis Abietic acid Biosynthesis Carbocations Carboxylic acids Potential energy surfaces Enzymes
Online Access:	View this record in EBSCOhost