Alcohol Attenuates Activation in the Bilateral Anterior Insula during an Emotional Processing Task: A Pilot Study †.
Aims: Alcohol acutely reduces agitation and is widely used in social situations, but the neural substrates of emotion processing during its intoxication are not well understood. We examine whether alcohol's social stress dampening effect may be via reduced activity in the cortical systems that subse...
| Publicado en: | Alcohol & Alcoholism Vol. 46; no. 5; pp. 547 - 553 |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
Sep/Oct2011
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=64854754&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 64854754 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07350414 FA3 jtl: Alcohol & Alcoholism issn: 07350414 maglogo: N pubinfo: dt: Sep/Oct2011 vid: 46 iid: 5 pid: 622 pub: Oxford University Press / USA artinfo: ui: 64854754 104675927 104675927 10.1093/alcalc/agr066 64854754 ppf: 547 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Alcohol Attenuates Activation in the Bilateral Anterior Insula during an Emotional Processing Task: A Pilot Study †. aug: au: Padula, Claudia B. Simmons, Alan N. Matthews, Scott C. Robinson, Shannon K. Tapert, Susan F. Schuckit, Marc A. Paulus, Martin P. affil: Department of Psychology , University of Cincinnati , 4150 Edwards Building One, PO Box 210376, Cincinnati, OH 45221 , USA sug: subj: Ethanol Cognition Emotions Alcoholic Intoxication Oxygen Blood Cerebral Cortex Physiopathology Cerebral Cortex Drug Effects Human Pilot Studies Magnetic Resonance Imaging Alcoholic Beverages Male Female Adult Descriptive Statistics Semi-Structured Interview Breath Tests Summated Rating Scaling Data Analysis Software Repeated Measures Multivariate Analysis of Variance Anger Fear Happiness Basal Ganglia Drug Effects Funding Source Interview Guides Psychological Tests Scales Adult: 19-44 years Male Female ab: Aims: Alcohol acutely reduces agitation and is widely used in social situations, but the neural substrates of emotion processing during its intoxication are not well understood. We examine whether alcohol's social stress dampening effect may be via reduced activity in the cortical systems that subserve awareness of bodily sensations, and are associated with affective distress. Methods: Blood oxygen level-dependent activation was measured through 24 functional magnetic resonance imaging sessions in 12 healthy volunteers during an emotional face-processing task following ingestion of a moderate dose of alcohol and a placebo beverage. Results: Results revealed that bilateral anterior insula response to emotional faces was significantly attenuated following consumption of alcohol, when compared with placebo (clusters >1472 μl; corrected P < 0.05). Conclusion: Attenuated response in the anterior insula after alcohol intake may explain some of the decreased interoceptive awareness described during intoxication. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|