Can sodium valproate improve learning in children with epileptiform bursts but without clinical seizures?
This study aimed to determine whether sodium valproate (VPA) improves cognitive performance and behaviour in children with learning and behavioural problems associated with electrographic epileptiform discharges but without clinical seizures. A randomized, double-blind, single-crossover trial was ca...
| Publicado en: | Developmental Medicine & Child Neurology Vol. 42; no. 11; pp. 751 - 756 |
|---|---|
| Autores principales: | , , , , , , , , , |
| Formato: | clinical trial research randomized controlled trial Journal Article |
| Publicado: |
Wiley-Blackwell
Nov2000
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=64877548&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 64877548 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00121622 1VN jtl: Developmental Medicine & Child Neurology issn: 00121622 maglogo: Y pubinfo: dt: Nov2000 vid: 42 iid: 11 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 64877548 64877548 NLM11104347 64877548 10.1111/j.1469-8749.2000.tb00038.x NLM11104347 64877548 ppf: 751 ppct: 5 formats: tig: atl: Can sodium valproate improve learning in children with epileptiform bursts but without clinical seizures? aug: au: Ronen, Gabriel M Richards, Joanne E Cunningham, Charles Secord, Margaret Rosenbloom, David Ronen, G M Richards, J E Cunningham, C Secord, M Rosenbloom, D affil: Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada sug: subj: Anticonvulsants Therapeutic Use Child Behavior Disorders Drug Therapy Learning Disorders Drug Therapy Epilepsy Complications Valproic Acid Therapeutic Use Learning Disorders Etiology Epilepsy Drug Therapy Male Child Female Human Treatment Outcomes Attention Crossover Design Double-Blind Studies Child Behavior Disorders Etiology Clinical Trials Validation Studies Comparative Studies Evaluation Research Multicenter Studies Randomized Controlled Trials Child Behavior Checklist Scales Child: 6-12 years Male Female ab: This study aimed to determine whether sodium valproate (VPA) improves cognitive performance and behaviour in children with learning and behavioural problems associated with electrographic epileptiform discharges but without clinical seizures. A randomized, double-blind, single-crossover trial was carried out with VPA or placebo on eight participants with different learning and behaviour problems. Participants also underwent neuropsychological testing under video EEG and the parent and teacher Behaviour Check List (CBCL; Achenbach 1991a, b) during each treatment phase. Clinically none of the children improved on VPA. On formal testing children were more distractable, had increased delay in response time, and showed lower memory scores while on VPA. In addition, parents reported higher internalizing scores on the CBCL while children were on VPA. Our data do not support the use of VPA in similar patients. pubtype: Academic Journal doctype: clinical trial research randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|