Occurrence of aflatoxin M and exposure assessment in Catalonia (Spain).
Background: Aflatoxin M (AFM) is the main monohydroxylated derivative of aflatoxin B (AFB) formed in liver and excreted into milk. Although AFM is less toxic than AFB, it has been classified as a possible human carcinogen, Group 2B agent by International Agency for Research on Cancer (IARC). Objecti...
| Publicado en: | Revista Iberoamericana de Micologia Vol. 27; no. 3; pp. 130 - 136 |
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| Autores principales: | , , , , |
| Formato: | Artículo |
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Elsevier B.V.
Sep2010
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=lth&AN=65483385&site=ehost-live header: @attributes: shortDbName: lth uiTerm: 65483385 longDbName: MedicLatina uiTag: AN controlInfo: bkinfo: jinfo: jid: 11301406 PVP jtl: Revista Iberoamericana de Micologia issn: 11301406 maglogo: N pubinfo: dt: Sep2010 vid: 27 iid: 3 pid: 467 pub: Elsevier B.V. artinfo: ui: 65483385 10.1016/j.riam.2010.05.003 ppf: 130 ppct: 6 formats: fmt: @attributes: type: P size: 167KB tig: atl: Occurrence of aflatoxin M and exposure assessment in Catalonia (Spain). aug: au: Cano-Sancho, German Marin, Sonia Ramos, Antonio J. Peris-Vicente, Juan Sanchis, Vicente affil: Food Technology Department, University of Lleida, XaRTA-UTPV, Lleida, Spain su: Aflatoxins International Agency for Research on Cancer Enzyme-linked immunosorbent assay Dairy products Carcinogens Milk Catalonia (Spain) Spain sug: subj: Catalonia (Spain) Spain Aflatoxins International Agency for Research on Cancer Enzyme-linked immunosorbent assay Dairy products Carcinogens Milk keyword: Aflatoxin M1 Aflatoxina M1 Evaluación de la exposición Exposure assessment Incidencia Modelo probabilístico Monte Carlo Occurrence Probabilistic model Aflatoxina M1 Evaluación de la exposición Incidencia Modelo probabilístico Monte Carlo ab: Background: Aflatoxin M (AFM) is the main monohydroxylated derivative of aflatoxin B (AFB) formed in liver and excreted into milk. Although AFM is less toxic than AFB, it has been classified as a possible human carcinogen, Group 2B agent by International Agency for Research on Cancer (IARC). Objectives: The objectives of this study were (i) to determine the occurrence of AFM1 in the main dairy products consumed in Catalonia region (Spain), and (ii) to assess the exposure of Catalonian population to aflatoxin M through deterministic and probabilistic method. Methods: Occurrence of Aflatoxin M (AFM) was determined in 72 composites of milk, 72 composites of cheese and 72 composites of yoghurt from Catalonia. AFM content was analysed using an Enzyme-Linked ImmunoSorbent Assay commercial kit. Three approaches to exposure assessment were conducted: one deterministic method and two probabilistic models with Monte Carlo simulations. Results: AFM was detected in 94.4% (68/72) of whole UHT milk samples, in 2.8% (2/72) of yoghurt samples and not detected in cheese. The maximum level was detected in one yoghurt sample with 51.58 ng/kg, only this sample being over the legal EU limit of 50 ng/kg. Milk, cheese and yoghurt mean concentrations were 9.29 ± 2.61, < 12.5 and 13.22 ± 4.82 ng/kg, respectively. Conclusions: According to these values, it should be expected Catalonian population is not exposed to a significant risk from aflatoxin M1 including average and high consumers. Antecedentes: La aflatoxina M (AFM) es el principal derivado mono-hidroxilado de la aflatoxina B (AFB), formado en el hígado y excretado en la leche. A pesar de que la AFM es menos tóxica que la AFB1, ha sido clasificada como un posible carcinógeno para los humanos, en el Grupo 2B por la Agencia Internacional para la Investigación del Cáncer (IARC). Objetivos: i) Determinar la incidencia de AFM en los principales productos lácteos consumidos en Cataluña (España), y ii) evaluar la exposición de la población catalana a esta micotoxina. Métodos: La incidencia de AFM, se determinó en 72 composites de leche, 72 composites de queso y 72 composites de yogur procedentes de Cataluña. La concentración de AFM1 se analizó con un kit comercial de Ensayo por Inmunoabsorción Ligado a Enzimas (ELISA). En la evaluación de la exposición, se llevaron a cabo tres aproximaciones: un método determínistico y dos modelos probabilísticos mediante simulación por el método Monte Carlo. Resultados: Finalmente, se detectó en el 94,4% (68/72) de las muestras de leche, en el 2,8 % (2/72) de las muestras de yogur, y no se detectó en las muestras de queso. Las concentraciones medias de leche, queso y yogur fueron 9,29 ± 2,61, < 12,5 and 13,22 ± 4,82 ng/kg, respectivamente. Conclusiones: Según estos valores, no se debería esperar que la población catalana esté expuesta a niveles significativos de riesgo derivados de AFM1, incluyendo grandes consumidores. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y custom: Copyright of Revista Iberoamericana de Micologia is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. item: Revista Iberoamericana de Micologia holder: Elsevier B.V. dt: @attributes: year: 2010 holdings: @attributes: islocal: N |
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