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Pentoxifylline for treatment of venous leg ulcers: a systematic review.

Introduction: Venous ulcers are usually treated with compression therapy, but, because this treatment may not be effective for some people, adjuvant therapy could be beneficial. We did a systematic review of randomised controlled trials that compared pentoxifylline (with and without compression trea...

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Published in:Lancet Vol. 359; no. 9317; pp. 1550 - 1555
Main Authors: Jull, Andrew, Waters, Jill, Arroll, Bruce
Format: research Journal Article
Published: Lancet 5/4/2002
Online Access:View this record in EBSCOhost
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      dt: 5/4/2002
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      pub: Lancet
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        10.1016/S0140-6736(02)08513-6
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      tig:
        atl: Pentoxifylline for treatment of venous leg ulcers: a systematic review.
      aug:
        au:
          Jull, Andrew
          Waters, Jill
          Arroll, Bruce
      sug:
        subj:
          Pentoxifylline Therapeutic Use
          Vasodilator Agents Therapeutic Use
          Leg Ulcer Drug Therapy
          Bandages and Dressings
          Administration, Oral
          Vasodilator Agents Administration and Dosage
          Leg Ulcer Therapy
          Human
          Pentoxifylline Administration and Dosage
          Chi Square Test
          Clinical Trials
      ab: Introduction: Venous ulcers are usually treated with compression therapy, but, because this treatment may not be effective for some people, adjuvant therapy could be beneficial. We did a systematic review of randomised controlled trials that compared pentoxifylline (with and without compression treatment) with placebo, or other treatments, in patients with venous leg ulcers.Methods: We identified eight trials (547 adults), five of which compared pentoxifylline and compression with placebo and compression (n=445), and three of which compared pentoxifylline alone with placebo (102). Our main aim was to determine whether pentoxifylline, with or without compression, was effective in treatment of venous leg ulcers. Analysis was by intention to treat.Findings: Pentoxifylline was more effective than placebo in complete healing or substantial improvement of venous leg ulcers (relative risk 1.49, 95% CI 1.11-2.01). Pentoxifylline with compression was also more effective than placebo and compression in complete healing (1.30, 1.10-1.54). Patients taking pentoxifylline had no more adverse events than those on placebo (1.25, 0.87-1.80). The most frequent adverse event was mild gastrointestinal disturbance (43%).Interpretation: Our results suggest that pentoxifylline gives additional benefit to compression for venous leg ulcers, and is possibly effective for patients not receiving compression.
      pubtype: Academic Journal
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        Journal Article
      ougenre: Article
    language: English
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